Galectins and Cancer Biology

Galectin-9 binding to HLA-DR in dendritic cells controls immune synapse formation and T cell proliferation

This study shows that galectin-9 in dendritic cells is necessary for organizing HLA-II at immune synapses, which enhances CD4+ T cell activation and anti-tumor immunity.

Galectin-3 Mediated Endocytosis of the Orphan G-Protein-Coupled Receptor GPRC5A

This study identifies Galectin-3 as a novel ligand for GPRC5A, demonstrating its role in mediating endocytosis of the orphan GPCR in colorectal cancer cells.

Galectin-1 Modulates Hepatocellular Carcinoma Response to Thermal Ablation Through Regulating Glycolysis

This study identifies galectin-1 as a prognostic biomarker for predicting thermal ablation response in hepatocellular carcinoma and shows that targeting Gal-1 enhances ablation efficacy by modulating glycolysis.

Unraveling the GM1 specificity of Galectin-1 binding to lipid membranes

This study investigates Galectin-1's specificity for GM1 over GD1a in lipid membranes and finds no evidence of cross-linking by homodimers.

Synthetic and plant-derived multivalent galactans as modulators of cancer-associated galectins-3 and -9

The paper investigates plant-derived galactans as potential inhibitors of galectins-3 and -9, showing species-specific binding and their effects on pancreatic cancer cells.

Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis.

This paper investigates how galectin-3 enhances TGF-β1 activation and signaling in lung fibroblasts, contributing to idiopathic pulmonary fibrosis.

Neurons define non-myelinated axon segments by the regulation of galectin-4-containingaxon membrane domains

The paper identifies galectin-4 as a neuronal factor that establishes and regulates non-myelinated axon segments by forming membrane domains that exclude myelination.