Galectins and Cancer Biology

Whole-Blood Transcriptomics Highlights Galectin-1 in Systolic Blood Pressure

The paper identifies LGALS1 as the strongest galectin correlate of systolic blood pressure in African Americans using whole-blood transcriptomics.

Melanoma suppresses galectin-9-glycan axis in dendritic cells and galectin-9 restoration limits T regulatory cell expansion

This study shows melanoma suppresses galectin-9 on dendritic cells, and restoring it limits T regulatory cell expansion, suggesting a new therapeutic target.

A Developmental Lectin-Glycan Program Enables Early Breast Cancer Dissemination and Metastatic Onset

This study identifies a developmental GAL1-glycan program that promotes early breast cancer dissemination and metastasis by reactivating mammary stem cell traits and epithelial plasticity.

Galectin-1 identifies a unique subpopulation of highly invasive glioblastoma cells and enables their migration

This study identifies galectin-1 as a marker of invasive glioblastoma subpopulations and shows its role in promoting migration and tumor recurrence.

Galectin-8 Modulates Membrane CD44v Localization and Tempers STAT3 Signaling in Gastric Metaplasia

This study shows that galectin-8 modulates CD44v membrane localization and suppresses STAT3 signaling in gastric metaplasia, with implications for cancer prognosis.

Galectin-3 is Necessary for Selective Cathartocytosis, which Expedites the Development of Proliferative Gastric SPEM

This study shows galectin-3 promotes cathartocytosis in gastric chief cells, facilitating metaplasia development by enabling sulfomucin vesicle secretion.

Galectin-1 Modulates Cell Adhesions, Caveolae, and Vascular Permeability in Kidney Endothelial Cells -- Insights from Proteomics, Phosphoproteomics, and Functional Studies

This study shows that galectin-1 modulates cell adhesions, caveolae, and vascular permeability in kidney endothelial cells through proteomic and phosphoproteomic analyses.

Galectin-3 binds to the RGD-binding site in a glycan-independent manner and to the allosteric site and activates integrins αvβ3, αIIbβ3, and α5β1

This study shows Galectin-3 binds to integrins αvβ3, αIIbβ3, and α5β1 in a glycan-independent manner and activates them through two distinct sites, with implications for inflammation and thrombosis.

Galectin-9 binding to HLA-DR in dendritic cells controls immune synapse formation and T cell proliferation

This study shows that galectin-9 in dendritic cells is necessary for organizing HLA-II at immune synapses, which enhances CD4+ T cell activation and anti-tumor immunity.

Mapping galectin-3 ligands in tear fluid establishes spliceoform-dependent lacritin binding

This study identifies new Gal-3 ligands in tear fluid, showing that lacritin's glycoforms and spliceoforms specifically bind Gal-3, influencing its biological functions.

Multimerin1, not Galectin-8, Promotes Gastric Chief Cell Differentiation by Tempering WNT Signaling

The paper investigates the role of multimerin-1 in gastric chief cell differentiation by tempering WNT signaling, revealing its importance in epithelial maturation through interactions with mesodermal cells.

Galectin-3 Mediated Endocytosis of the Orphan G-Protein-Coupled Receptor GPRC5A

This study identifies Galectin-3 as a novel ligand for GPRC5A, demonstrating its role in mediating endocytosis of the orphan GPCR in colorectal cancer cells.

B7-H4 Binds Galectin-9 Glycosylation-Dependently and Attenuates Galectin-9-Mediated CD28/AKT Activation and T Cell Death

This study identifies Galectin-9 as a binding partner for B7-H4 and shows that their interaction modulates T cell activation and death, revealing a complex regulatory network in immune responses.

Galectin-1 Modulates Hepatocellular Carcinoma Response to Thermal Ablation Through Regulating Glycolysis

This study identifies galectin-1 as a prognostic biomarker for predicting thermal ablation response in hepatocellular carcinoma and shows that targeting Gal-1 enhances ablation efficacy by modulating glycolysis.

Unraveling the GM1 specificity of Galectin-1 binding to lipid membranes

This study investigates Galectin-1's specificity for GM1 over GD1a in lipid membranes and finds no evidence of cross-linking by homodimers.

Synthetic and plant-derived multivalent galactans as modulators of cancer-associated galectins-3 and -9

The paper investigates plant-derived galactans as potential inhibitors of galectins-3 and -9, showing species-specific binding and their effects on pancreatic cancer cells.

Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis.

This paper investigates how galectin-3 enhances TGF-β1 activation and signaling in lung fibroblasts, contributing to idiopathic pulmonary fibrosis.

A Genome-Wide CRISPR Screen Identifies Sortilin as the Receptor Responsible for Galectin-1 Lysosomal Trafficking

The paper identifies sortilin as the receptor mediating galectin-1 lysosomal trafficking through a CRISPR screen and demonstrates its use for siRNA delivery.

Galectin-3 depletion tames pro-tumoural microglia and restrains cancer cells growth

This study shows that Galectin-3 depletion reduces immunosuppressive microglia and limits cancer cell growth in brain tumours.

Neurons define non-myelinated axon segments by the regulation of galectin-4-containingaxon membrane domains

The paper identifies galectin-4 as a neuronal factor that establishes and regulates non-myelinated axon segments by forming membrane domains that exclude myelination.