RNA regulation and disease

Modulation of ADARs mRNA expression in congenital heart defect patients

The paper investigates changes in ADAR1 and ADAR2 mRNA expression in congenital heart defect patients and finds opposite expression patterns, suggesting ADAR2 may prevent cardiovascular defects.

Leveraging Endogenous ADAR for Programmable Editing on RNA

This paper introduces LEAPER, a method using endogenous ADAR proteins for targeted RNA editing, demonstrating its efficacy in restoring p53 function and catalytic activity in disease models.

Disruption in A-to-I editing levels affects C. elegans development more than a complete lack of editing

This study investigates the distinct roles of ADAR-1 and ADAR-2 in C. elegans by analyzing their effects on RNA editing, gene expression, and phenotypes when mutated individually.

Profiling Gene Specific Changes to RNA Editome in Preeclampsia

The paper identifies gene-specific RNA editing changes in hypoxic cell lines and preeclamptic fetuses, finding increased editing in cell lines and decreased in fetuses, with potential diagnostic markers identified.

Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in lymphocytes

This study shows that mitochondrial hypoxia induces APOBEC3G-mediated RNA editing in lymphocytes, leading to metabolic changes and reduced proliferation.

Illuminating spatial A-to-I RNA editing signatures within the Drosophila brain

The paper presents a spatial RNA editing map in the Drosophila brain, revealing distinct editing signatures across neuronal populations and identifying novel editing sites in conserved regions of essential neuronal genes.

Widespread cis-regulation of RNA-editing in a large mammal

The paper identifies cis-regulated RNA editing quantitative trait loci (edQTL) in cattle, linking them to gene expression and lactation traits.

Widespread RNA editing dysregulation in Autism Spectrum Disorders

This study identifies widespread hypo-editing in ASD brains and links RNA editing dysregulation to Fragile X syndrome through FMRP/FXR1P-ADAR interactions.

Dynamic landscape and genetic regulation of RNA editing in schizophrenia

The paper examines RNA editing changes in schizophrenia by analyzing postmortem brain samples and identifies genetic regulators and associations with schizophrenia GWAS loci.

Genome-wide analysis of consistently RNA edited sites in human blood reveals interactions with mRNA processing genes and suggests correlations with cell types and biological variables.

The paper identifies consistently RNA-edited sites in human blood, links them to RNA processing genes, and finds correlations with cell types and biological variables.

Identifying Changes in RNA Editome Unique to Major Depressive Disorder

The paper identifies 142 unique RNA editing sites in MDD patients using RNA sequence data from suicide cases and controls.

Differentiating Genomic SNPs Using Allele Depth and Predicted Genotype

The paper presents an R-based method to distinguish genomic SNPs from RNA editing sites using allele depth ratios and predicted genotypes, achieving 86-90% accuracy.

Dynamic temperature-sensitive A-to-I RNA editing in the brain of a heterothermic mammal during hibernation

The paper quantifies A-to-I RNA editing in hibernating ground squirrels and finds cold-induced editing sites that may provide neuroprotection during torpor.

Mechanistic Implications of Enhanced Editing by a HyperTRIBE RNA-binding protein

This paper introduces HyperTRIBE, an improved version of TRIBE that enhances RNA editing efficiency, leading to more accurate identification of RNA-binding protein targets.

In vivo RNA targeting of point mutations via suppressor tRNAs and adenosine deaminases

The paper demonstrates the use of suppressor tRNAs and ADAR2 for in vivo RNA targeting to correct point mutations in mouse models of genetic diseases.

Visualizing adenosine to inosine RNA editing in single mammalian cells

The paper develops an RNA FISH method to visualize adenosine-to-inosine editing in single cells and finds no correlation with nuclear localization or paraspeckle association.

Evidence for Transcriptome-wide RNA Editing Among Sus scrofa PRE-1 SINE Elements

The paper identifies widespread RNA editing in pig transcriptomes, showing ADAR-mediated A-to-G transitions, particularly in repetitive regions like the PRE-1 SINE retrotransposon.