Coenzyme Q10 studies and effects

UbiB proteins mediate an ATP-dependent decarboxylation step in bacterial ubiquinone biosynthesis

This study identifies UbiB as an ATP-dependent decarboxylase in bacterial ubiquinone biosynthesis, showing it can replace the UbiX/UbiD system in Escherichia coli.

COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating

This study identifies COQ8 as a chaperone that facilitates coenzyme Q biosynthesis by ATP-driven structural gating of intermediates.

L-2-hydroxyglutarate recycling is linked to coenzyme Q biosynthesis

The paper identifies L2HGDH as a component of the COQ metabolon, linking L-2-hydroxyglutarate recycling to coenzyme Q biosynthesis and showing its role in maintaining biosynthetic intermediates.

A method to synthesize analytical rhodoquinone standards for quantitative analysis in tissue specimen

The paper synthesizes and purifies rhodoquinone standards for absolute quantification in mammalian tissues and ETC studies.

Complete Enzyme Clustering Enhances Coenzyme Q Biosynthesisvia Substrate Channeling

The paper investigates how metabolon clustering enhances coenzyme Q biosynthesis through substrate channeling using simulations and experiments.

Tracing the Path from 4-Hydroxyphenylpyruvate to the Benzoquinone Ring of Q6 and the p-aminobenzoate pathway in Yeast

The paper identifies the 4-hydroxyphenylpyruvate pathway in yeast for synthesizing the benzoquinone ring of coenzyme Q6 and shows metabolic flexibility through the p-aminobenzoate pathway.

Statin-Induced Mitochondrial Coenzyme Q Deficiency Alters Mitochondrial Redox Homeostasis and Bioenergetic Function in Astrocytes

This study shows statin exposure reduces mitochondrial CoQ levels and impairs bioenergetics in astrocytes, but CoQ10 supplementation reverses these effects.

Reduction of Weight Gain by Modulating Mitochondrial Energy Coupling Efficiency Using a Bromo-Coenzyme Q10 analog (6-Br-Q0C10)

This study shows that 6-Br-Q0C10 reduces body weight gain in rats and confirms its effect on cell growth, suggesting potential for obesity and cancer management.

RatA is not a toxin but serves as a ubiquinone shuttle

The paper clarifies that RatA in E. coli is not a toxin but a ubiquinone shuttle, and proposes renaming it to UbiM.

Effects of the Coenzyme Q10 Analog 6-Bromo-ubiquinone (6-Br-Q0C10) on Mammalian Cell Growth

This study examines the effects of 6-Br-Q0C10 on cell proliferation across multiple cell lines, finding it inhibits growth with varying effectiveness, particularly in obesity-related and cancer cell lines.

Ubiquinone is a hysteretic modulator of the NADH:cytochrome b5 reductase activity of human Cb5R

This study investigates how ubiquinone analog CoQ0 modulates NADH:cytochrome b5 reductase activity in human Cb5R, showing hysteretic effects and altered kinetic parameters.

Redox hysteresis controls the NADH-dependent reduction of cytochrome b5 in rat microsomes

This study investigates the hysteresis in the NADH-dependent reduction of cytochrome b5 in rat liver microsomes, finding lag-time-dependent behavior linked to endogenous molecules.

Enhancing and stabilizing a high-yield industrial Rhodobacter sphaeroides strain for coenzyme Q10 production

This paper enhances CoQ10 production in Rhodobacter sphaeroides by engineering the PrrAB system and stabilizing the strain through CRISPRi, achieving 3.6 g/L in pilot-scale fermentation.

Fmp30 is a phosphatidylinositol hydrolase that regulates CoQ biosynthesis

The paper identifies Fmp30 as a phosphatidylinositol hydrolase that negatively regulates CoQ biosynthesis in yeast by affecting lipid metabolism.

Characterization of a COQ8A-ataxia mouse model with E548K single-site mutation: distinct and comparable findings relative to a loss-of-function mutation

This study characterizes a COQ8A-ataxia mouse model with a E548K mutation, finding no significant motor or cognitive impairments despite biochemical changes similar to a knockout model.

Coenzyme Q10 alleviates the mitochondrial damage by high-fat load in hepatocytes of spotted seabass (Lateolabrax maculatus) via promoting mitophagy

This study shows coenzyme Q10 improves mitochondrial function and reduces fat accumulation in seabass hepatocytes by promoting mitophagy.

ADCK4 deficiency destabilizes the coenzyme Q complex, which is rescued by 2,4-dihydroxybenzoic acid treatment

This study shows ADCK4 deficiency causes CoQ10 deficiency and mitochondrial dysfunction in podocytes, which is rescued by 2,4-dihydroxybenzoic acid treatment.

Alternative splicing of COQ-2 determines the choice between ubiquinone and rhodoquinone biosynthesis in helminths

The paper shows helminths switch from ubiquinone to rhodoquinone synthesis via alternative splicing of coq-2 in anaerobic environments.