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Small Intestinal Submucosa (SIS)-dECM Bioink with Extrusion-Induced Collagen Organization for Tympanic Membrane Tissue Engineering

This study develops a bioink using decellularized small intestinal submucosa to create a printable scaffold that promotes collagen organization for tympanic membrane regeneration.

Whole-organ surface mapping using multiview projection reconstruction

This paper introduces PRISM, a method for whole-organ surface mapping using multiview projection reconstruction, enabling efficient and accurate surface feature analysis in biological samples.

Effect of alginate encapsulation on growth and viability of polycyclic aromatic hydrocarbon-degrading bacteria varies by environment, species, and capsule design

The paper evaluates how alginate encapsulation affects growth and viability of PAH-degrading bacteria under different environmental conditions and capsule designs.

Engineering xylose metabolism for diverse polyhydroxyalkanoates synthesis in Halomonas TD

This paper engineers Halomonas TD to produce diverse polyhydroxyalkanoates from xylose and glucose, achieving high yields of PHB and terpolymers through pathway modifications.

Targeted analysis of chondrocyte central metabolites in response to cyclical compression and shear deformations

This study investigates how cyclical compression and shear deformations affect central metabolites in chondrocytes, showing changes in metabolites that could inform therapeutic mechanotransduction for cartilage repair.

Assessing the translation of AI-prioritized genome-derived peptide fragments into validated antimicrobial candidates

This study evaluates AI-prioritized antimicrobial peptides derived from Malassezia furfur genomes, showing their antimicrobial activity and highlighting AI prediction biases.

vFLIM: Machine Learning-enabled Light Sheet Fluorescence Lifetime Imaging

The paper introduces a machine learning-enabled pipeline for volumetric FLIM imaging in living systems, enabling long-term and high-speed data acquisition and analysis.

Multifunctional Rare-Earth-Ion-Doped Si-HAp Platforms Modulate Human BMSC Lineage-Associated Molecular Responses Without Enhancing Terminal Differentiation

This study evaluates how Li+, Eu3+, and Gd3+ co-doped Si-HAp affects BMSC lineage-associated molecular responses without enhancing terminal differentiation.

MyoAssist 1.0: An Open-Source Framework for Neuromechanical Simulation of Physical Human-Device Interaction

MyoAssist 1.0 provides an open-source framework for simulating human-device interaction in assistive technologies, offering modular models and controller frameworks for research and development.

Colloidal DNA nanoaggregates applied towards file-partitioning for information storage and dynamic data obfuscation

This paper demonstrates the use of colloidal DNA/RNA nanoaggregates for data storage and obfuscation by encoding digital information into oligo libraries and manipulating ionic strength.

A rapidly deployable CRISPR-Cas3 diagnostic platform for emerging RNA viruses

This paper develops a CRISPR-Cas3-based diagnostic platform for emerging RNA viruses, enabling rapid assay design and deployment with high sensitivity and portability.

Dark CO2 Fixation via the Ethylmalonyl-CoA Pathway Establishes Metabolic Parity: A Stoichiometric Basis for Compounding Ecosystem Shifts

The paper shows glycogen-accumulating organisms use the ethylmalonyl-CoA pathway for CO2 fixation to achieve metabolic parity with polyphosphate-accumulating organisms, leading to community shifts through stoichiometric advantages.

Tail length of triazine-based lipids influences blood clotting risk in vitro and in vivo

The paper evaluates triazine-based lipids with varying tail lengths for pulmonary mRNA delivery, finding that C14 tail length reduces thrombosis risk in vitro and in vivo.

Low-cost monophasic transcranial magnetic stimulator

This paper presents a low-cost monophasic TMS device that can exceed average human motor thresholds under specific modeling assumptions.

HydroMEA: A 3D Hydrogel Based Microfluidic Device to Study Electrophysiology for Myelinated Nerve-on-Chip

The paper introduces hydroMEA, a 3D hydrogel-based microfluidic device that enables real-time electrophysiological measurements of myelinated nerve-on-chip systems using human iPSC-derived neurons and Schwann cells.

VEGFR-2 Phosphorylation at Y1054 or Y1214 is Necessary for Mechanically-Induced Angiogenesis

This study shows that phosphorylation of VEGFR-2 at Y1054 or Y1214 is required for mechanical-induced angiogenesis, highlighting the role of tumor mechanics in vessel growth.

Spatial profiling of pooled mRNA-LNP delivery in vivo with NanoSTAMP

This paper introduces NanoSTAMP, a spatially resolved in vivo screening platform for barcoded LNPs, linking formulation to cell-type uptake and tissue responses.

Temporal dynamics improves machine learning-based prediction of cell state from quantitative phase imaging

This study shows that 3D spatiotemporal CNNs outperform 2D CNNs in classifying cell states from QPI timelapse data, with accuracy improving as more frames are added.

Scaffold-mediated delivery of a miRNA-29b mimic mitigates excessive extracellular matrix deposition and matrix contraction in wound healing applications

This paper develops a collagen-GAG scaffold delivering miRNA-29b to reduce fibrosis by inhibiting myofibroblast activation and ECM accumulation in wound healing.

Standardizing mechanical dose delivery to cells via nanogroove-guided alignment

This study introduces a method to standardize mechanical dose delivery to cells by aligning them using nanogrooved substrates, resulting in uniform mechanical responses across cell populations.