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Surface functionalization of small extracellular vesicles derived from Caco-2 and HEK293T cells in the neutralization of Shiga toxin 1 subunit B

This study develops glycoengineered small extracellular vesicles (sEVs) decorated with Gb3 to neutralize Shiga toxin 1 subunit B, showing effective binding and reduced toxin activity without harming cell viability.

Computational Analysis of Fibroblast Subpopulation Dynamics as a Driver of Fibrotic Foci Formation

This paper develops a multiscale computational model to study how Thy-1 expression in fibroblast subpopulations influences fibrotic foci formation in IPF.

Dual-Specific Antibody Design Using Artificial Intelligence

This paper designs functional multibodies using AI, demonstrating their therapeutic potential with high affinity and specificity across multiple targets.

A lipid nanoparticle platform for high yield CRISPR-targeted homology directed repair enables fully non-viral CAR T cell generation

This paper develops a lipid nanoparticle (LNP) platform for non-viral CRISPR-mediated homology directed repair (HDR) to generate CAR T cells with improved efficiency and reduced toxicity compared to electroporation.

Stepped Cyclic Strain, that Increases or Decreases as Hierarchical Collagen Fibers Form, Does not Further Improve Maturation in Engineered Ligaments

This study tests stepped cyclic strain during collagen fiber formation in engineered ligaments and finds it does not improve maturation beyond existing methods.

Genetic and Biochemical Characterization Reveals PduU as a Modular Tool for Tuning Pdu Microcompartment Permeability

This study shows that modifying PduU, a shell protein in bacterial microcompartments, tunes permeability without disrupting structure, enhancing propionate production.

Bioorthogonal Tethering of FGF18 to Annealed Microgel Scaffolds Enhances Cartilage Repair

This paper develops FGF18-tethered microgel scaffolds to enhance cartilage repair by optimizing surface charge and growth factor presentation.

Bio-mimicked Leaf-Imprinted Topographies: Pattern Characterization and Cell Response

This paper uses leaf-imprinted topographies to study cell alignment and response, finding that specific leaf patterns significantly influence cell aspect ratio and alignment.

Using Latent Chemical Recognition in an Evolved Periplasmic Binding Protein Family to Diversify Biosensors

The paper screens a family of evolved biosensors against diverse ligands to identify cross-reactive compounds, finding multiple ligands beyond neural drugs that activate the sensors.

Epitope-Focused Immunogens Confer Broad Protection against Coronaviruses

This study designs epitope-focused immunogens targeting conserved coronavirus regions, showing broad neutralizing activity and protection in mice against diverse coronaviruses.

A Compact, Standalone & Battery-Powered 3D Organoid-on-Chip System with Programmable Flow Control

The paper introduces a compact, battery-powered organoid-on-chip system with programmable flow control, validated for culturing pancreatic cancer organoids and showing enhanced proliferation and drug response.

Meditope-Enabled Chimeric Antigen Receptors Facilitate Plug-and-Play Control of T Cells

This study develops meditope-enabled CARs to improve T cell functionality and address tumor heterogeneity in CAR therapy.

A novel in vitro assay for quantifying endothelial cell and pericyte interactions

This paper introduces a high-throughput co-culture system to study endothelial cell and pericyte interactions and validates its use in assessing disease-relevant stimuli and therapeutics.

Parameter-Dependent Effects of Spinal Cord Stimulation on Neural Activation and Evoked Compound Action Potentials

This study uses computational models to investigate how anatomical and stimulation parameters affect ECAPs during spinal cord stimulation, revealing trade-offs and optimization strategies.

Inverse-scattering of absorptive samples via beam propagation

This paper extends an inverse-scattering framework to reconstruct complex-valued refractive index, including absorptivity, by combining angle-varying illumination and sample defocus measurements.

Architecture-Dependent Stability, Cellular Uptake, and Redox Modulation of Poly(p-Coumaric Acid) Hybrid Nanoparticles for Ovarian Carcinoma Intervention

This paper develops hybrid nanoparticles with improved stability and redox activity for ovarian cancer treatment and imaging.

Identifying and engineering the molecular origins of lignin color for predictive staining of plant tissues.

The paper identifies lignin chromogens responsible for plant tissue color and demonstrates genetic engineering to predictably stain lignified tissues.

Programmable DNA Nanocages Enhance Levodopa Delivery for Neuroprotection in a Zebrafish Model of Parkinson's Disease

This study uses DNA nanocages to deliver Levodopa in a zebrafish Parkinson's model, improving neuroprotection and reversing disease symptoms.

A pyramidal silicon nanopore for single misfolded Tau protein characterisation

This paper presents a pyramidal silicon nanopore for label-free characterisation of misfolded Tau proteins using resistive pulse sensing, enabling discrimination of different Tau species based on electrical fingerprints.

HaloMPNN: retraining ProteinMPNN on halophilic proteomes for salt-tolerant enzyme design

This paper retrained ProteinMPNN on halophilic proteomes to design salt-tolerant enzymes, showing HaloMPNN shifts protein properties toward halophilic traits.