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Aptamer charge-amplified field-effect transistor biosensors achieve picomolar detection limits for small-molecule biomarkers in complex biological matrices

This paper develops a charge-amplified FET biosensor for detecting small-molecule biomarkers with picomolar sensitivity in complex biological samples.

A robust and user-agnostic step-emulsion platform for scalable microgel fabrication

This paper introduces a step-emulsion platform for scalable microgel fabrication that is robust, user-agnostic, and compatible with various materials and viscosities.

DNA Double-decker Ring Scaffolded Nanodisc for Self-assembly of Membrane Protein into Lipid Bilayer

This study introduces a DNA-based nanodisc scaffold for membrane protein assembly, demonstrating its compatibility with various lipids and detergents.

Generalized Normative Modeling: A One-Step Hierarchical Kernel Framework for Multi-Site Brain Charts with Self-Correcting Z-Scores

This paper introduces GNM, a hierarchical framework for multi-site brain normative modeling that produces site-invariant z-scores and preserves age-related signals better than existing methods.

Rapid receptor internalization potentiates CD7-targeted lipid nanoparticles for efficient mRNA delivery to T cells and in vivo CAR T-cell engineering

This paper compares T-cell receptor-targeted lipid nanoparticles for mRNA delivery, finding CD7-targeting achieves highest efficiency due to rapid internalization.

Real-time volumetric imaging of cells and molecules in deep tissues with Takoyaki ultrasound

This paper introduces a 3D ultrasound imaging method called Takoyaki to visualize contrast agents and reporter genes in living organisms, demonstrating its use in in vitro and in vivo settings.

3D Printed Customizable Radiopaque Markers for Assessing Gastrointestinal Transit

This paper introduces 3D printed radiopaque markers for GI transit studies, showing they enable tunable geometry and improved tracking in live rats.

PlasmidLM: A Promptable DNA Language Model via Verifiable-Reward Post-Training

PlasmidLM is a DNA language model that generates plasmid constructs from component specifications, achieving high fidelity and viability in generated sequences.

Physics-informed multi-encoder adaptive optics enables rapid aberration correction for intravital microscopy of deep complex tissue

MeNet-AO corrects optical aberrations in intravital microscopy using a multi-encoder network, improving imaging in zebrafish and mouse tissues.

A Novel Rotation-Mitigation Technology for Cycling HelmetsTested Across Helmet Types, Impact Locations and Headforms

This paper introduces a novel helmet technology, the Release Layer System (RLS), which reduces rotational energy during impacts, significantly lowering the risk of brain injury.

Comparison of two different finite element modeling pipelines for virtual mechanical testing of the distal third metacarpal bone in Thoroughbred racehorses

This study compares two finite element modeling pipelines for predicting subchondral bone strain in Thoroughbred racehorses, finding that one is more accurate but computationally intensive than the other.

Identification and characterization of a Fibrillin-1 derived matrikine for cardiac regeneration and repair

This study identifies a fibrillin-1 derived peptide that enhances cardiomyocyte proliferation and reduces fibroblast activation, suggesting potential as a cardiac regeneration therapy.

Developmentally inspired bioprinting of nascent multicellular human heart tissue through in situ differentiation and morphogenesis of iPSCs

This paper develops a bioprinting method that mimics embryonic heart development by enabling in situ differentiation of iPSCs into cardiac tissues within shape-morphing constructs.

A reduced order multibody model of the foot and ankle complex based on kinematic synergies

This paper introduces a reduced-order multibody model of the foot and ankle complex using kinematic synergies, achieving high accuracy in reconstructing bone-level kinematics with fewer markers.

Discriminative Site-Directed Protein Engineering via Lightweight CASPE Platform

CASPE is a lightweight platform for site-directed protein engineering that improves the identification of beneficial mutations for thermostability and pH tolerance.

An extracellular vesicle biogenesis-inspired engineering platform for efficient protein delivery and therapeutic base editing

This paper introduces a platform for efficient protein delivery using extracellular vesicles engineered with biogenesis-inspired features, achieving functional gene editing in vitro and in vivo.

An Adjustable Offloading Ankle-Foot Orthosis: Design and Proof-of-Concept Biomechanical Verification

This paper introduces an adjustable ankle-foot orthosis (OLAFO) that provides controlled offloading during gait, demonstrating its feasibility through biomechanical testing in an able-bodied participant.

Expanding the scope of redox-balance growth coupling techniques with a carbon cofeeding strategy

This paper introduces a carbon cofeeding strategy to overcome stoichiometric limitations in redox-balance growth coupling, enabling growth-coupled selection for biosynthetic pathways in engineered E. coli.

Micromechanical characterisation of osteoarthritic subchondral bone by micropillar compression

This study uses micropillar compression and imaging to analyze mechanical properties of subchondral bone in osteoarthritis, finding increased strength in trabeculae but unchanged modulus, with mineralization as a key determinant.

Ultrasensitive, Low-Input Detection of Avocado Sunblotch Viroid via RPA-CRISPR and Nanopore-Array Single-Bead Fluorescence Readout

This paper develops a low-input, ultrasensitive diagnostic platform for detecting Avocado Sunblotch Viroid using RPA-CRISPR and nanopore-array fluorescence readout, achieving a detection limit of 1.68 copies/L.