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This paper develops a mechanochemical model to predict nuclear deformation and lamina remodeling in response to substrate nanotopography and validates predictions through experiments.

This study investigates how calcium ions affect the structure and aggregation of the A53T mutant of α-synuclein, revealing structural changes in fibril formation.

The paper introduces new tools in RELION-5.1 for automated processing and analysis of cryo-EM images of amyloid filaments, demonstrating their application on experimental datasets.

This study shows reflectin proteins form liquid-liquid phase-separated condensates that mirror spatial organization in squid skin Bragg lamellae, controlled by charge density and protein proportions.

This study determines the cryo-EM structure of human TMEM260, revealing its mechanism for O-mannosylation of key receptors and providing insights into related congenital disorders.

This study quantifies how mutations affect IAPP amyloid formation using deep mutational scanning and identifies key residues involved in aggregation.

This study investigates how NuMA activates dynein and regulates microtubule dynamics during mitosis using structural and functional analyses.

This study investigates dark state-mediated photobleaching in mCherry-based RFPs, showing photodestructive dark states and providing insights for engineering brighter and more photostable probes.

This study identifies cysteine residues as critical for tau aggregation and propagation in cells, both spontaneously and when seeded.

This paper redesigns β-barrel nanopores for stable insertion into thick block copolymer membranes, enabling efficient detection and translocation of biomolecules.

This paper shows that slow migration can help eliminate cooperative antimicrobial resistance in time-varying spatial environments by enhancing extinction probability of resistant bacteria.

This paper introduces a FLIM-FRET method to quantify membrane-proximal alpha-synuclein aggregation in neurons by estimating per-cell lifetimes and mixture fractions using a hierarchical EM algorithm.

This study uses molecular dynamics simulations to show Ang 1-7 stabilizes the inactive conformation of MasR and induces limited activation through non-canonical micro-switch dynamics.

This paper introduces a standardized framework to quantify MS2 VLP reassembly yields and identifies key parameters affecting reassembly efficiency.

AlphaSAXS uses SAXS data to guide AI in reconstructing accurate protein conformations, improving upon sequence-only models by incorporating experimental constraints.

This study uses advanced optical microscopy to track collagen remodeling in the murine cervix during gestation, revealing spatio-temporal changes that begin in the lower cervix by day 12 and spread by day 15.

This paper uses coarse-grained simulations and reflectivity data to study RNA-lipid interactions at interfaces, showing how RNA structure affects binding and validating simulation results with experimental data.

The paper introduces edENM, an elastic network model refined for DNA, RNA, and protein-nucleic acid complexes, showing better agreement with experimental data than previous models.

The paper shows spatially correlated fluctuations slow relative chromatin motion in living cells, affecting gene regulation.

This paper introduces a wash-free method for multi-target super-resolution microscopy using photocaged DNA labels, demonstrating improved imaging accuracy without sample manipulation.