Discover, rate, and discuss biology preprints.

This study uses computational modeling and human brain stimulation to show that 1/f noise enhances neural synchrony more effectively than white noise.

The paper develops a biophysical model to elucidate how Spo0A[~]P binding to its regulatory boxes affects spo0A transcription in Bacillus subtilis, revealing repressive effects and the role of RNAP holoenzyme levels in expression increase.

This paper introduces Meta-rLLS-VSIM, a super-resolution microscopy technique that achieves near-isotropic resolution with reduced training time and data requirements.

This study shows that amylin aggregates faster on fibrillar collagen, leading to β-cell death and dysfunction, which accelerates diabetic progression.

The paper investigates how mutations in BK channel β subunit residues affect inactivation by altering access to the central cavity through the side portal pathway.

This study maps how phosphorylation patterns shape β-arrestin structure and function using simulations and machine learning, revealing isoform-specific allosteric responses and effector engagement.

This study shows that LC8 bridges 53BP1 trimers to enhance 53BP1 foci formation, which is critical for DNA repair.

This study introduces Glycan Atlassing, a method using DNA-tagged lectin labeling and metabolic oligosaccharide engineering to map glycocalyx architecture at nanometer resolution, revealing spatial relationships that reflect cellular state.

This paper introduces nonlinear singular value decomposition beamforming for ultrasound imaging of gas vesicles, achieving comparable sensitivity to existing methods with fewer pulse transmissions and improved signal-to-background ratio.

This study uses molecular dynamics simulations and Markov state models to analyze histone tail conformations and shows acetylation increases H2B tail dynamics.

This study uses molecular dynamics simulations to show that transient interdomain interactions in Httex1 modulate its structural ensemble and self-assembly, contributing to aggregation in Huntington's disease.

This paper identifies a tau peptide fragment that forms seeding-competent fibrils and shows how the P301L mutation facilitates its aggregation into 4R tauopathy-like structures.

This paper introduces DiffPIE, a physics-guided method to predict protein conformations under external interactions without retraining, showing success in cyclic peptides and gold-surface adsorption.

This study develops DNA-based receptors in synthetic membranes that respond to cations, enabling controlled assembly and catalytic activity, mimicking biological signaling mechanisms.

This study investigates the thermogenic function of opossum UCP1 and finds that altered residues K100 and Y289 do not account for its lack of thermogenic activity.

PyPE_RESP is a tool for deriving RESP charges with multi-conformer and multi-molecule support, providing constraint group and non-constraint group charges.

This study examines how blast-induced traumatic brain injury affects cellular mechanics and differentiation in hippocampal progenitor cells using shockwave exposure and mechanical analysis.

This study identifies a pre-active intermediate in GPCR activation and shows how dimer interactions influence signaling efficacy and functional diversity.

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

This study uses advanced imaging systems to detect ultraweak photon emission (UPE) from live and dead mice and stressed plants, revealing differences in UPE intensity under various physiological conditions.