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Microenvironmental Fingerprint of Maturing Tau Condensates from Spectral and Lifetime Phasor Analysis of a Solvatochromic Dye

This paper develops a multimodal framework using spectral and lifetime phasor analysis to characterize microenvironmental changes in Tau condensates during maturation.

Dual-reporter assay for selective small molecule inhibition of expanded toxic huntingtin

The paper introduces a dual-reporter assay to screen small molecules for selective inhibition of expanded toxic huntingtin, identifying artifacts and validating compounds.

A Deformulating Multi-Attribute SEC Method for Simultaneous Quantification of Total RNA, Conjugated Antibody, and Free Antibody in Targeted Lipid Nanoparticles

This paper introduces an online deformulating SE-HPLC method to simultaneously quantify total RNA, conjugated antibody, and free antibody in targeted lipid nanoparticles.

Engineering Nanobody Conformational Switches

This paper engineers conformational switches using nanobodies that fold upon ligand binding, enabling customizable receptors and sensors for biomarkers and drugs.

Nanomechanical phenotyping uncovers a non-canonical smooth muscle-like hypercontractility program in lung squamous cell carcinoma myofibroblasts

The paper identifies a non-canonical smooth muscle-like hypercontractility program in LUSC myCAFs using nanomechanical phenotyping, linking it to tumor mechanics and adverse outcomes.

FACT frees Ubp10 from nucleosome sequestration after rapid H2B deubiquitination

The paper shows that FACT facilitates Ubp10 release from nucleosomes after H2B deubiquitination, revealing release as the rate-limiting step for Ubp10 turnover.

Frequency-Dependent Structural Responses of Amyloid-β Fibrils to Terahertz Pulses: A Nonequilibrium Molecular Dynamics Study

This study uses nonequilibrium molecular dynamics to show frequency-dependent structural changes in amyloid fibrils under terahertz pulses, identifying two electric-field thresholds for disruption.

Maximum Likelihood Localization Maps

This paper introduces a non-iterative method to create molecular probability maps from single-molecule localization data, preserving positional likelihood without coordinate-based rendering.

Temperature-dependent Fano resonance in Microtubules and Tubulin investigated with Spontaneous Raman Spectroscopy

The paper measures Raman spectra of microtubules and tubulin at various temperatures to investigate Fano resonance asymmetry in molecular bond vibrations.

Quantum Entanglement as a Physical Determinant of Genomic Instability in TP53

The paper explores whether quantum entanglement, measured via von Neumann Entropy, influences TP53 mutation patterns, finding elevated entropy at known mutational hotspots but cautioning about limited validation.

Lysenin Induced Membrane Curvature on Erythrocytes and Nanoporous Mica Free Standing Membranes

This study shows lysenin pores induce membrane curvature into rigid dome-like structures, suggesting beta-PFTs alter host cell membranes beyond pore formation.

Distributed Network Sensing as an Escape Strategy

The paper shows that slime mould networks can detect and escape harmful environments through reconfiguration, depending on their size and connectivity.

Highly conserved talin isoforms encode distinct mechanical responses and ligand-binding capabilities

This study examines how sequence differences between talin-1 and talin-2 affect their mechanical responses and ligand-binding capabilities, revealing distinct mechanical behaviors and new interaction sites in talin-2.

Predicting the alternative conformation of a known protein structure based on the distance map of AlphaFold2

This study shows that AlphaFold2 distance maps can reveal multi-state protein structures, enabling prediction of alternative conformations with high accuracy.

Amyloid stability and condensate material properties independently govern the hnRNPA2 condensate to fibril transition

This study shows that amyloid structure and condensate stability independently influence the hnRNPA2 condensate-to-fibril transition, revealing a structural framework for this process.

Multi-scale biophysical modeling of fungal colony growth

This paper develops a multiscale model of fungal colony growth combining discrete hyphal mechanics with a stochastic traveling-wave surrogate to simulate growth efficiently and reveal macroscopic patterns.

Structural Basis of Second-Generation HIV-1 Maturation Inhibitor Activity by Magic Angle Spinning NMR

This study uses MAS NMR to determine the binding mode of HRF-4467, a second-generation HIV-1 maturation inhibitor, in the CA-SP1-NC11 complex with IP6, revealing its mechanism of action and resistance profile.

Organised streaming of cerebrospinal fluid in the human third ventricle

The paper investigates how pressure pulses from cardiac and respiratory activity generate CSF motion in the human third ventricle and shows how increasing Reynolds number affects residual streaming.

siRNA/mRNA payload of lipid nanoparticles quantified using fluorescence microscopy and correlation spectroscopy

The paper quantifies mRNA and siRNA payload in lipid nanoparticles using fluorescence microscopy and FCS, showing size-dependent payload and coencapsulation dynamics.

Opposing Roles of Cholesterol and Cholesterol Sulfate in Proton Transfer and Diffusion at Membrane Interfaces

This study shows cholesterol and cholesterol sulfate have opposing effects on proton transfer and diffusion at membrane interfaces, with cholesterol promoting local transfer and inhibiting long-range diffusion, while cholesterol sulfate does the opposite.