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This study introduces tripartite antibiotic regimens that reverse bacterial resistance by cycling through three drugs, leading to resensitization and reduced fitness costs.

This study compares old and new local ancestry inference methods in Hispanic/Latino populations using HCHS/SOL data, finding high similarity but some regional discrepancies.

The paper models how deleterious mutations affect genomic diversity during population bottlenecks and range expansions, finding that dominance levels influence diversity preservation and trough formation.

This study identifies KLHL41's role in sarcomere assembly and muscle growth in zebrafish models of nemaline myopathy, revealing its importance in myofibril formation and cross-bridge regulation.

The paper presents a curated dataset and web application for analyzing ancient DNA from Britain and Ireland, enabling non-experts to explore genetic connections between ancient and modern populations.

This study introduces two RTEL1 mouse models with distinct mutations at amino acid 492, showing that M492K affects telomere length while M492I impairs telomere protection, leading to different disease phenotypes.

The paper introduces Joint-Cabernet, a single-cell platform for profiling 5hmC and 5mC, and applies it to mouse brain nuclei to study DNA hydroxymethylation changes with aging.

REMEDY enables efficient repair of heterozygous mutations in human and mouse cells without exogenous donor DNA by using CRISPR-induced DSBs and HDR enhancers.

The paper develops an algorithm to estimate asymmetric migration rates in population genetic models and applies it to datasets from poplar trees, gray wolves, and humans, revealing complex migration patterns.

The paper uses CRISPR-Cas9 to edit the bantam gene in Drosophila, revealing variability in NHEJ-induced deletions and HDR outcomes.

This study investigates the role of KLF12 in regulating proliferation and apoptosis of rabbit ovarian granulosa cells, revealing its impact on follicular development and hormone secretion.

The paper identifies five SNPs in the DDX6-CXCR5 locus associated with autoimmune diseases and shows their functional effects on gene regulation in immune and epithelial cells.

The paper identifies a magnesium transporter, SLC41A2, as critical for primate cardiac pacemaker function using a mouse lemur model of arrhythmias.

This study compares CRISPR-mediated homology-directed repair (HDR) and prime editing (PE) for precise genetic variant knock-in in zebrafish, finding PE achieves higher editing efficiency and fewer off-target effects.

The paper shows that inducing proteinuria enhances viral vector transduction of renal tubule epithelial cells after intravenous administration.

The paper analyzes pentanucleotide tandem repeats in human genomes using long-read sequencing, revealing extensive variability and evolutionary origins.

The paper introduces a statistical framework to estimate haplotype frequencies, multiplicity of infection, and linkage disequilibrium from multi-allelic markers, validated on malaria data from Cameroon.

The paper identifies functionally conserved regulatory elements across distantly related vertebrates despite sequence divergence using a synteny-based method.

This study identifies HUWE1 as a regulator of WNT signaling through two mechanisms: antagonizing destruction complex-mediated β-catenin degradation and an independent pathway, both requiring HUWE1's ubiquitin ligase activity.

The paper identifies candidate causal cis-regulatory variants at electrocardiographic QT interval GWAS loci by integrating open chromatin data and expression quantitative trait loci.