Discover, rate, and verify biology preprints.

Genetic diversity of endangered Acropora spp. corals in Bonaire: implications for restoration and gene banking

The paper assesses genetic diversity in Acropora spp. corals in Bonaire, finding high genotypic richness and capturing significant microsatellite diversity, with no genetic structuring among subpopulations.

Expression of tardigrade intrinsically disordered proteins in C. elegans reveals variable effects on aging and stress

Constitutive somatic expression of four tardigrade disordered proteins shortened C. elegans lifespan and healthspan and gave little stress protection. Three of the four reduced polyQ aggregation under hyperosmotic stress.

X-Chromosomal STR-based analysis of genetic diversity, structure, and phylogeny in the Sri Lankan Vedda population

This study analyzes X-chromosomal STR diversity in the Vedda population, finding significant genetic differentiation from other South Asian groups and highlighting their unique genetic heritage.

Advancing global DNA-referencing of bushmeat in African tropical forests: a tool for identifying trade hotspots and dynamics in western and central Africa

The paper develops a DNA-typing reference database to trace bushmeat trade in Africa, identifying species and trade hotspots with high accuracy.

A centromere but not just a centromere: structure and evolution of a selfish chromosomal supergene in monkeyflowers

The paper analyzes the structure and evolution of a selfish centromere in monkeyflowers, identifying genomic expansions and gene content differences that may contribute to meiotic drive.

Eco-evolutionary Dynamics of Colonization: When Does Source Selection Matter?

This study uses simulations to show balancing selection in source populations increases colonization success in new habitats when founder populations are small, regardless of environmental conditions.

SMFnet reveals principles of combinatorial transcription factor assembly

The paper introduces SMFNet and PRISM to analyze how transcription factor assemblies influence chromatin accessibility and identifies sequence-encoded principles of combinatorial TF assembly.

Fss1, a CTNS/PQ domain protein, has dual roles in promoting fertility in Schizosaccharomyces pombe

Fission yeast Fss1, a PQ-loop membrane protein, acts in diploids to build full-thickness, chitin-containing spore walls and within spores to maintain vacuole morphology and timely germination.

The globally dispersed sun-coral species is _Tubastraea coccinea_ (Cnidaria: Anthozoa)

The paper resolves taxonomic confusion in sun corals by combining molecular phylogenetics and genome assemblies, revealing T. coccinea as the cosmopolitan species and T. tagusensis as endemic to the Galapagos.

End-To-End, Fully Automated Manufacturing of Hematopoietic Stem and Progenitor Cell Therapy Via CCR5-Targeted Integration

This paper demonstrates an automated, high-throughput platform for manufacturing gene-edited hematopoietic stem and progenitor cells (geHSPCs) with preserved function and in vivo engraftment capacity.

kri-1/KRIT1 restrains skn-1/NRF2 activation to promote innate immune and lipid homeostasis

This study identifies kri-1/KRIT1 as a regulator that limits skn-1/NRF2 activity to control immune responses and lipid homeostasis in C. elegans, supporting reproductive health.

BLocPRS: locus-aware ensembles of polygenic scores provide accurate linear prediction

BLocPRS improves polygenic risk score prediction by combining locus-specific weights from different PRSs, achieving higher accuracy in UK Biobank and extending to non-European populations.

The Alzheimer's disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures

This study identifies the rs28834970 variant in PTK2B as a risk factor for Alzheimer's disease, showing it impairs PYK2 function, increases Tau phosphorylation, and alters APP processing in human neuronal cultures.

Astroglial Dysfunction in Models of CDKL5 Deficiency Disorder

This study generates novel human models of CDKL5 Deficiency Disorder and identifies astrocytic dysfunction in these models.

POSH (Plenty of SH3): a novel genetic modifier of Myc function in Drosophila

This study identifies POSH as a genetic modifier of Myc function in Drosophila through a genetic screen and functional analysis.

Pedigree-tracking improved population monitoring of recessive disease-causing alleles in pedigreed canine populations

The paper uses probabilistic inference in pedigreed canine populations to estimate disease-causing allele frequencies more comprehensively than genetic tests alone, showing improved monitoring of recessive diseases.

Preclinical Development and Safety of Laterally Spreading Dual AAV.SPR-MYO7A Vectors for the Treatment of Usher Syndrome Type 1B

This paper develops and tests dual AAV vectors for treating USH1B by reconstituting full-length MYO7A expression, showing safety and efficacy in non-human primates.

Yra2 regulates proteolysis of Cse4 to prevent its mislocalization to non-centromeric regions for chromosomal stability in budding yeast

This paper identifies Yra2's role in ubiquitin-mediated proteolysis of Cse4 to prevent its mislocalization and maintain chromosomal stability in budding yeast.

Human infection with an ape Plasmodium vivax-like parasite

The paper reports a case of human infection with an ape-like Plasmodium vivax parasite, identified through whole-genome sequencing, suggesting zoonotic transmission from wild gorillas and chimpanzees.

The nonsense-mediated decay RNA-surveillance pathway facilitates the hypoxia response by C. elegans

This study identifies a functional interaction between the HIF-1 hypoxia response pathway and the NMD RNA surveillance pathway in C. elegans, showing NMD enhances specific aspects of the HIF-1 response.