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This study shows that TLR4 signalling selectively regulates lipid transport proteins in human macrophages but not in mouse macrophages, highlighting species-specific differences in immune-lipid interactions.

This paper develops a scalable method to generate pure CD103+ cDC1 from mouse bone marrow cultures, achieving high purity and yield for immunological studies.

This study shows that repeated CBD administration in rats reduces splenic lymphocyte numbers via CB2 receptors, similar to its effects in peripheral blood.

This study shows that bivalent natalizumab inhibits VLA-4 adhesion more effectively than monovalent Fab fragments under shear stress, suggesting kinetic and geometric factors are critical for therapeutic efficacy.

This paper identifies immunomodulatory endothelial cells (IMEC) that present antigens on MHC class II and activate T cells in atherosclerosis.

The paper introduces a method using Imaris to track PET-defined lung inflammation sites in Mtb-exposed NHPs, showing correlation with traditional methods and providing additional lesion features.

This study identifies a mechanism by which CD1c presents two lipids simultaneously, with bulky headgroups oriented sideways, enabling autoreactive TCR recognition.

This study isolates and characterizes neutralizing antibodies against HCoV-229E, showing one antibody induces conformational changes in the viral spike protein.

The paper identifies and characterizes VIP-R antagonists with high-affinity and potent anti-leukemia activity through in silico screening, in vitro testing, and in vivo validation.

This study investigates how ImmTACs activate suppressed cytotoxic T cells, finding they can induce cytolysis but not IFN-gamma secretion, and enhance CTL polarization and calcium signaling.

This study identifies PTM-mimic peptides that enhance T cell responses to Sjogrens Disease autoantigens by altering HLA-DR3 binding affinity and epitope presentation.

ImmunoStruct improves immunogenicity prediction by integrating peptide-MHC sequence, structure, and biochemical data, showing better performance than existing methods.

This study investigates AIM2's role in CD4+ T cell activation and homeostasis, finding it promotes IL-2 production in vitro but not essential for in vivo functions like tumor control.

The paper investigates how antibody affinity maturation and light-chain pairing contribute to neutralizing evolved SARS-CoV-2 variants, identifying mechanisms that enable anticipatory immune breadth.

The paper demonstrates that delivering FLT3L with CXCL9 and CCL5 enhances cDC1 infiltration and antitumor immunity in mice and humanized models.

This study shows that antigen encounter in the epidermis enhances TRM persistence and proliferation through TGF{beta} signaling and TGF{beta}RIII expression.

This study shows that a fiber-rich diet alters alveolar macrophage metabolism and lung injury responses via gut microbiome-derived propionate.

This study identifies P7-Pen as a peptide that enhances monocyte inflammatory responses in sepsis by modulating histone acetylation through ABHD14B.

The paper examines the cross-sectional association between dietary supplements and anti-HAV antibodies using NHANES data, finding no significant association overall but a significant positive link with vitamin D.

This study shows that poly(I:C) reprograms myeloid cells in rhabdoid tumors, enhancing CD8+ T cell infiltration and improving response to PD-1 blockade.