B. Zhang

The paper evaluates synthetic cytokines to enhance NK92 cell production and performance, finding that membrane-bound cytokines improve cytotoxicity and expansion.

This paper introduces SMLFM, a volumetric super-resolution microscopy technique that achieves higher speed and accuracy in detecting single molecules in live cells.

This paper develops bispecific antibody shuttles targeting CD98hc for efficient and long-lived brain delivery of IgGs, showing improved retention and specificity compared to TfR-1 shuttles.

This study builds an isoform-resolution transcriptomic atlas of colorectal cancer using long-read single-cell sequencing and identifies neoepitopes for vaccine development.

OpenABC simplifies GPU-accelerated simulations of biomolecular condensates using Python, offering performance comparable to hundreds of CPUs and tools for converting to all-atom structures.

This study shows RBP-J regulates blood Ly6Clo monocytes and their derived lung macrophages by controlling CCR2 expression.

The paper shows that micropolarity differences between subcompartments dictate the structural organization of biomolecular condensates, leading to layered structures and functional changes.

This study uses simulations and experiments to show that diblock polypeptides form interfacial environments due to hydrophilic-hydrophobic residue distribution, affecting condensate stability and hydrogen bonding.

This study reports cryo-EM structures of HCAR2-Gi1 complexes with agonists, revealing ligand recognition, selectivity, and activation mechanisms for drug design.

This study screens six non-antibiotic growth promoter combinations in vitro to improve feed efficiency and broiler health by evaluating digestibility, microbiota, and antioxidant capacity.

This paper introduces a hierarchical strategy using CXMS and AlphaFold2 to analyze protein dynamics in vivo, focusing on IDPs and multi-domain proteins.

This paper introduces an efficient algorithm to convert Hi-C data into contact energies, revealing chromatin loop anchors and enabling 3D structure prediction.

This paper introduces smART FRET, a method that improves distance sensitivity in single-molecule studies by using acceptor rise time, enabling both closer and longer distance measurements with higher precision.

This paper develops an amber-free HIV-1 system for in-virus protein labeling, enabling smFRET analysis of Env conformational dynamics without disrupting structural integrity.

This paper develops a T cell engager that uses IFNγ to upregulate CD38 on leukemia stem cells, enabling their targeting and depletion in AML.

The paper identifies a stress-response gene network linked to CD1C-CD141 dendritic cells that correlates with prognosis in burns and COVID-19.

This study shows that MGA deletion drives Richter's transformation by modulating mitochondrial OXPHOS through the MGA-NME1 axis, suggesting a new therapeutic target.

This study identifies the mechanisms of Schisandrin B in treating diabetic nephropathy using network pharmacology and quantitative proteomics in rats.

This study evaluates six nonantibiotic growth promoters in broilers, finding they improve nutrient utilization, intestinal morphology, and microbial composition compared to control and enramycin.

This study shows that an amino acid-enriched elemental diet reduces mucolytic bacteria and protects the mucus layer in mice with colitis.

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

The paper identifies a novel ER-to-nucleus signaling pathway mediated by iRhom2 cleavage by the signal peptidase complex, linking it to psoriasis and TOC.

This study identifies Rnf as the key enzyme for propionate formation in Prevotella species via the succinate pathway, supported by genomic, proteomic, and enzymatic analyses.

The paper introduces a kinetic model to study how chromatin folding and histone modifications influence epigenetic stability through dynamic asymmetry.

This paper introduces a vortex ultrasound technique for endovascular sonothrombolysis that significantly improves clot lysis rates in cerebral venous sinus thrombosis.

The paper describes the Children's Brain Tumor Network (CBTN), a consortium that collects and shares multi-omic data and biospecimens to advance research on pediatric brain tumors.

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

This paper identifies a broadly neutralizing antibody from a snakebite survivor that protects against multiple snake venoms by targeting conserved neurotoxin epitopes.

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.

This study investigates the distinct roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of factor V and factor VIII, revealing that MCFD2 binds cargo and LMAN1 acts as a shuttling carrier.