B. Zhang

The paper shows that extravascular spaces, not the bloodstream, are the main source of antigenic diversity in Trypanosoma brucei infections, with over 75% of VSGs found exclusively in these spaces.

This paper identifies a novel C. elegans pathway involving nck-1 and the actin cytoskeleton that mediates defense against bacterial pore-forming proteins, independent of MAPK signaling.

This study identifies a common mechanism for temperature sensing in TRPM8 and TRPV1 thermoTRP channels through water-protein interaction changes.

This study investigates neuroinflammation in neuronopathic Gaucher disease by examining microglia and NK cells in mouse models, showing that Gba rescue in these cells reduces neuroinflammation and improves survival.

This study simulates the human genome using active forces to show their impact on heterochromatin localization and long-range spatial correlations.

This study shows that insulin receptor loss delays mammary tumor onset and burden in mouse models, without affecting progression or metastasis.

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

This paper develops a prefusion-stabilized Lassa virus GPC, identifies a neutralizing nanobody, and reveals a cleavage-dependent site of vulnerability at the trimer apex.

The paper improves an anti-malarial antibody using an in silico pipeline, resulting in a variant with higher binding affinity and better malaria protection.

The paper introduces cgRNASP, a series of coarse-grained statistical potentials for RNA 3D structure evaluation, showing comparable or better performance than all-atom methods with higher efficiency.

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

This study shows that disrupting the FabH gene in E. coli reduces its resistance to antibiotics by compromising the cell envelope, making previously ineffective antibiotics effective again.

The paper presents high-resolution cryo-EM structures of the full-length human AE1 transporter in various states, revealing substrate binding, inhibition mechanisms, and lipid/sterol binding sites.

This study characterizes the HERV-K (HML-8) group in the human genome, identifying 40 proviruses and 5 solo LTR elements and determining their integration time and genomic distribution.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

This study shows that Numb is essential for skeletal muscle function, as its knockout reduces force, alters mitochondrial structure, and affects calcium dynamics in mice.

The paper identifies core bacterial taxa and mobile genetic elements associated with extracellular antibiotic resistance genes in water compartments.

The paper designs and produces molecular probes for SARS-CoV-2 variants to assess immune responses and isolate neutralizing antibodies.

The paper identifies potent monoclonal antibodies that neutralize the B.1.1.529 SARS-CoV-2 variant and reveals structural mechanisms enabling their effectiveness.

This study identifies that PGE2-EP2 signaling suppresses lung ILC2 responses and eosinophilic inflammation, while EP4 agonism restricts these responses, offering potential therapeutic targets for asthma and NERD.

This paper introduces and validates a DESS wipe-based method for stool collection and preservation, showing high accuracy and diversity maintenance compared to freezing and commercial kits.

This study identifies Zfp335 as a transcription factor regulating T cell development by controlling TCRβ expression and cell survival through β-selection-dependent and -independent mechanisms.

This study uses polymer simulations to model how the diploid human genome organizes relative to nuclear bodies, showing that co-phase separation explains genome compartmentalization and spatial arrangement.

This study shows that prolonged heterochronic parabiosis reduces biological age and extends lifespan in mice through long-term epigenetic and transcriptomic changes.

This paper derives analytic expressions to predict multi-way chromatin contacts from Hi-C data, showing good correlation with experimental measurements.

This study shows ligand binding causes intracellular conformational changes in monomeric EGFR, linking extracellular and intracellular regions through the transmembrane helix.

This paper identifies a novel pectin from Syzygium aromaticum that strongly inhibits SARS-CoV-2 replication by binding to 3CLpro, PLpro, and RdRp enzymes.

The paper identifies fast-growing bacterial variants that avoid antibiotic accumulation and survive treatment without genetic mutations, challenging the current understanding of antibiotic resistance mechanisms.

This study identifies ten Shaker K+ channel genes in foxtail millet and analyzes their expression under abiotic stresses and ABA treatment, revealing distinct regulation patterns.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.