C. Wang

This study identifies a rare case where closely related fungi produce structurally distinct beauveriolide analogs, challenging fungal chemotaxonomy and revealing insights into BGC evolution and virulence.

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

This paper performs population pharmacokinetics analysis of camrelizumab and finds no significant advantage of flat-dose or weight-based dosing regimens.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This study assesses the effectiveness of riverine water eDNA for monitoring aquatic and riparian biodiversity, finding it effective for detecting species and bioinformation in specific conditions.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

The paper identifies p16INK4a+ mesenchymal cells in the lung basement membrane as reparative sentinels that transition to a senescence-associated secretory phenotype to support epithelial repair.

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

This study shows human alveolar type 2 cells can transdifferentiate into KRT5+ basal cells in 3D organoids, a process linked to IPF pathology and not observed in murine cells.

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

VipariNama uses RNA vectors to rapidly reprogram plant gene expression, enabling quick changes in morphology and metabolism across multiple species.

This study reports the crystal structure of a far-red-sensing cyanobacteriochrome and identifies key protein-chromophore interactions that enable far-red light perception.

The study identifies two thermal ecotypes within a nearly genetically identical Synechococcus population, showing functional diversity in temperature adaptation.

The paper functionally reconstitutes and structures the MCU-EMRE mitochondrial Ca2+ uniporter complex from Tribolium castaneum, revealing its tetrameric architecture and EMRE's role in Ca2+ uptake.

This paper describes the design of a fusion protein using human ferritin to present the SARS-CoV-2 spike glycoprotein RBM, suggesting it as a potential vaccine candidate.

This paper introduces a microfluidic device that creates a dual-oxygen environment for studying intestinal epithelial and bacterial interactions without external chambers.

This study shows JNK signaling promotes dental papilla cell polarization by regulating polarity-related genes and RhoA activity during tooth development.

This study identifies three Npl4 conformational states in the human p97 complex using cryo-EM and shows how a disulfiram derivative inhibits p97 by disrupting Npl4 zinc finger interactions.

This study identifies TAZ as an inhibitor of GR that regulates hepatic glucose homeostasis by modulating gluconeogenic gene promoter binding.

This study evaluates Ripasudil's effects on pigmentary glaucoma in a porcine model, showing reduced trabecular meshwork stress fibers, restored phagocytosis, and normalized intraocular pressure.

This study shows that inhibiting the NLRP3 inflammasome improves ovarian function and fertility in aging mice by enhancing AMH, autophagy, and reducing FSH and estradiol levels.

This study identifies humanized single domain antibodies that neutralize SARS-CoV-2 by targeting the spike receptor binding domain, showing improved activity when fused with the Fc region.

This paper develops a multiplexed CRISPR/Cas9 system with Trex2 exonuclease to improve genome editing efficiency in Setaria viridis, achieving high mutation rates and MMEJ-mediated repair.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

This study classifies and analyzes the expression of heat shock proteins in wheat infected with powdery mildew and stripe rust, revealing structural diversity and differential expression patterns.

The paper demonstrates that glucose production and disposal are inversely coupled in vivo, regardless of insulin target site, and shows this coupling persists despite metabolic challenges.

Sulfopin, a selective Pin1 inhibitor, reduces tumor initiation and growth in neuroblastoma models by targeting c-Myc pathways.

The paper identifies the C-shaped dimeric structure of FIP200's N-terminal domain and its role in organizing the ULK complex by directly binding ATG13.

This study shows that LZTR1 inactivation in glioblastoma stabilizes RIT1, leading to MAPK/ERK pathway activation and promoting tumor growth.