C. Wang

Isolation of cross-reactive monoclonal antibodies against divergent human coronaviruses that delineate a conserved and vulnerable site on the spike protein

This study isolates two cross-reactive monoclonal antibodies against multiple Betacoronaviruses, identifying a conserved vulnerable site on the spike protein.

Integrated characterization of SARS-CoV-2 genome, microbiome, antibiotic resistance and host response from single throat swabs

This study uses TRACE-seq to analyze single throat swabs, integrating SARS-CoV-2 genome, microbiome, antibiotic resistance, and host response data.

Protein Structure Determination via Distance GeometryStructural Similarity based Initialization

This paper introduces a distance geometry method for protein structure determination using structural similarity initialization, achieving high accuracy with limited distance data.

Repetitive and Brief Occlusion of the Majority of the Vena Cava Flow Attenuates Pulmonary Arterial Hypertension and Improves IK+ of the Pulmonary Arterial Smooth Muscle Cells in Rat Models: a novel potential therapeutic strategy for PAH

Heat Stress Interferes with Formation of Double-Strand Breaks and Homolog Synapsis in Arabidopsis thaliana

This study shows heat stress inhibits meiotic recombination in Arabidopsis by reducing DSB formation and homolog synapsis, affecting chromosome axis stability and recombinase levels.

A human monoclonal antibody targeting a conserved pocket in the SARS-CoV-2 receptor-binding domain core

This paper identifies a human monoclonal antibody, 47D11, that targets a conserved hydrophobic pocket in the SARS-CoV-2 RBD, revealing its structural basis for neutralization and potential therapeutic use.

Transcriptome analysis of potato leaves in response to infection with the necrotrophic pathogen Alternaria solani

This study analyzes the transcriptome of potato leaves infected with Alternaria solani to identify gene expression changes and hormone responses associated with disease resistance.

PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates

This study identifies how PTP-MEG2 regulates exocytosis by dephosphorylating specific sites on NSF, DYNAMIN2, and MUNC18-1, revealing distinct structural mechanisms for substrate recognition.

Cerebrospinal fluids from healthy pregnant women does not harbor a detectable microbial community

This study analyzes cerebrospinal fluid from healthy pregnant women and finds no evidence of a detectable microbial community after accounting for contamination.

Clear optically matched panoramic access channel technique (COMPACT) for large-volume deep brain imaging

The paper introduces COMPACT, a technique that significantly increases tissue access volume for deep brain imaging, enabling multiregional calcium imaging of deep brain functions associated with sleep.

Tripartite holobiont system in a vent snail broadens the concept of chemosymbiosis

The paper investigates the genomic basis of symbiosis in a vent snail, revealing a tripartite holobiont system involving host, endosymbionts, and gut microbiota, highlighting metabolic flexibility and mutualistic interactions.

Keratin5-BMP4 mechanosignaling regulates reciprocal acetylation and methylation at H3K9 to define blastema cell remodeling during zebrafish heart regeneration

This study identifies a Krt5-BMP4 mechanosignaling pathway that regulates histone modifications and blastema cell remodeling during zebrafish heart regeneration.

Characterization of SOX2, OCT4 and NANOG in ovarian cancer tumor-initiating cells

This study evaluates SOX2, OCT4, and NANOG expression in ovarian cancer cell lines under 2-D and 3-D culture conditions, finding SOX2 is more strongly associated with tumor-initiating cells and chemotherapy resistance.

Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly.

The paper identifies azetidine derivatives that kill Mycobacterium tuberculosis without resistance by inhibiting mycolate assembly, showing a novel mode of action and favorable pharmacological profiles.

Synthetic Cellular Immunity based on CAR repertoire for Human Immunotherapy

This paper demonstrates that engineered T cell libraries with CAR constructs can recognize nonself-antigens, expand clonally, persist, and show immunologic memory against tumors in murine models.

Highly potent anti-SARS-CoV-2 multivalent DARPin therapeutic candidates

This paper develops potent anti-SARS-CoV-2 DARPin therapeutics with low picomolar neutralization efficacy and reports their protective efficacy in a hamster model.

SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model

This study shows that high-dose convalescent plasma or monoclonal antibodies protect hamsters from SARS-CoV-2-induced lower respiratory disease, but lower doses are ineffective.

The specialization of Esteya vermicola hyphae in infection to Bursaphelenchus xylophilus and its colonization of pine tree

This paper investigates how Esteya vermicola colonizes pine trees and interacts with Bursaphelenchus xylophilus, revealing specific infection mechanisms and colonization patterns in healthy and infected trees.

SARS-Cov-2-, HIV-1-, Ebola-neutralizing and anti-PD1 clones are predisposed

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

Membrane Nanoparticles Derived from ACE2-rich Cells Block SARS-CoV-2 Infection

This paper develops membrane nanoparticles from ACE2-rich cells that effectively block SARS-CoV-2 infection by trapping the viral S1 protein and inhibiting its interaction with host cells.

Investigation of white spot syndrome virus (WSSV) infection in wild crustaceans in the Bohai Sea

This study investigates WSSV infection in wild crustaceans in the Bohai Sea, finding high prevalence rates and confirming infection through electron microscopy.

Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing

This study investigates how different surface topographies of biomaterial scaffolds affect skin wound healing in mice, finding that aligned scaffolds enhance regeneration and modulate immune responses.

Feature selection and causal analysis for microbiome studies in the presence of confounding using standardization

This paper introduces a method to identify microbiome features affecting outcomes while controlling for confounding variables, showing improved accuracy in agricultural microbiome studies.

The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

This study shows that CHMP5 regulates bone formation by controlling endolysosome-mitochondrion-mediated cell senescence, and targeting senescent cells can alleviate musculoskeletal abnormalities.

The role of CLV1, CLV2 and HPAT homologs in nitrogen-regulation of root development

This study examines the role of CLV1, CLV2, and HPAT homologs in nitrogen-regulation of root development in pea and tomato, finding species-specific effects.

The COP9 Signalosome Suppresses Cardiomyocyte Necroptosis

This study shows that Cops8/CSN deficiency in cardiomyocytes leads to necroptosis via the RIPK1-RIPK3 pathway, with Nrf2 and redox stress playing key roles.

Quorum Sensing Regulates 'swim-or-stick' Lifestyle in the Phycosphere

This study shows that quorum sensing regulates bacterial attachment to diatom surfaces, with symbionts producing QS signals that promote colonization while an opportunistic bacterium lacks these signals.

Quantitative proteomics reveals the protective effects of ESD against osteoarthritis via attenuating inflammation and modulating immune response

This study uses quantitative proteomics to show ESD reduces inflammation and modulates immune response in OA, protecting joints and cartilage.

Comparison of manual and machine learning image processing approaches to determine fungiform papillae on the tongue

This paper compares manual and machine learning methods for counting fungiform papillae on the tongue, finding strong correlations between automated and manual counts but no significant link between papilla density and PROP bitterness ratings.

The role of CLV signalling in the negative regulation of mycorrhizal colonisation and nitrogen response of tomato

This study identifies CLV signaling components involved in negatively regulating mycorrhizal colonization and nitrogen response in tomato.