C. Zhang

This study identifies a mutual regulatory loop between PFKP and VEGF that promotes glioblastoma growth through AKT-mediated signaling and glycolytic enhancement.

The paper shows that BR signaling is attenuated in stomatal precursor cells but remains active in differentiating epidermal cells, mediated by scaffold proteins.

The paper analyzes metagenomic and metatranscriptomic data from cold seeps to identify As-cycling genes and microbes, revealing unexpected diversity and functional roles in arsenic transformation.

This study investigates how N-glycosylation sites on SLC3A2 evolve and regulate amino acid transport and redox balance, revealing their role in cellular trafficking and bird evolution.

This study identifies a signaling cascade involving GxcM, Fbp17, RacC, and WASP that regulates rear cortical actin assembly in migrating Dictyostelium cells.

The paper measures the bending stiffness of the bacterial flagellar hook under counterclockwise and clockwise rotations, finding it doubles under clockwise rotation.

The paper demonstrates that syncytin-mediated open-ended membrane tubular connections enable efficient intercellular transfer of Cas9 protein, unlike closed-ended connections or EVs.

This study shows APOBEC3B edits R-loops at ER enhancers, leading to DSBs that contribute to genomic instability in breast cancer.

The paper introduces MTIST, a platform for benchmarking microbial ecosystem inference tools using simulated time series data and an ecological sign score.

This study shows that loss of maternal linker histone H1 in Arabidopsis facilitates DME-mediated demethylation in heterochromatin but has limited effects on endosperm gene transcription and imprinting.

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

The paper reports cryo-EM structures of PTH1R bound to PTH and PTHrP, revealing molecular mechanisms of hormone recognition and selectivity.

The paper develops a base editor-mediated pipeline in E. coli to screen for functional single nucleotide variants under industrial stress conditions, identifying known and novel mutations.

The paper traces the evolutionary origin of brackish archaea, showing gene rearrangements enabled their adaptation to coastal environments after the Cryogenian Snowball Earth.

This paper identifies a microbiome guild-level signature associated with COVID-19 severity and prognosis using metagenomic analysis of fecal samples.

The paper maps global land sharing-sparing patterns between humans and wildlife using human-nature indices and classifies lands into four categories based on biodiversity and human pressure.

The paper introduces an event-driven acquisition framework that enhances microscopy by capturing dynamic biological events with optimized imaging rates.

This paper identifies LPD-3 as a conserved megaprotein critical for lipid trafficking between ER and PM, essential for cold resilience in C. elegans and other species.

This study shows that combining SHP2 and autophagy inhibition effectively suppresses NF1-associated MPNSTs in mouse models, suggesting a potential new treatment approach.

The paper describes a high-throughput method to screen V-ATPase inhibitors/activators using Acridine Orange in yeast vacuoles.

The paper develops a model of Drosophila epithelium to show that mechanical responses depend on embryo geometry and cell topology, with apical surfaces being softer than basal ones.

The paper identifies novel resistance genes in Solanum americanum against Phytophthora infestans by analyzing genome variation and effector recognition.

This study identifies steroidal glycoalkaloids (SGAs) as contributors to anthracnose resistance in tomato, showing higher SGA accumulation and gene expression in resistant fruit.

This paper introduces ONE microscopy, a technique that enables nanoscale imaging of single proteins and molecular complexes, revealing structural details in cells and disease samples.

This study identifies and functionally predicts sugar beet circRNAs involved in drought responses using deep sequencing and network analysis.

This study shows that hypomorphic HD-PTP/PTPN23 mice develop lipodystrophy and reduced adipogenesis, indicating HD-PTP's role in insulin signaling and fat accumulation.

This study shows that osteocyte ablation in mice leads to senescence-associated changes in bone and bone marrow lineages, causing sarcopenia, osteoporosis, and shortened lifespan.

This study shows PANX3 is essential for maintaining skin architecture, adhesion, barrier function, and inflammation during aging, as demonstrated in knockout mice.