C. Zhang

This study introduces a high-resolution 3D single-particle tracking method to measure nanoscale forces and potentials in live cells using silver nanoparticles.

The paper reports the crystal structures of a humanised A33 Fab antibody variant targeting colorectal cancer, focusing on structural features of the grafted CDRs and switch linker.

This paper introduces a multifunctional anchor for expansion microscopy, enabling simultaneous imaging of multiple biomolecules with reduced cost and complexity.

The paper shows that loss of Spindly increases sensitivity of EML4-ALK v3 NSCLC cells to HSP90 inhibitors, but not v1 cells.

The paper shows that TIN1, an ER stress-induced protein in Arabidopsis, is selectively degraded by the ERAD complex during stress recovery, while other UPR-induced proteins remain stable.

The paper identifies Muribaculaceae family bacteria as pathobionts that induce insulin-dependent diabetes in mice through translocation to the pancreas following gut microbiota disruption.

The paper develops PxR3D-map to predict and characterize photo-crosslinking in protein-RNA complexes using structural data and crosslink site mapping.

This paper shows that a chitosan oligosaccharide analog disrupts fungal cell wall organization by targeting PHR transglucosidases, leading to antifungal activity and synergy with existing fungicides.

This study identifies fermentation of macromolecules as the dominant energy source for microorganisms in gas hydrate-bearing subseafloor sediments.

The paper compares exercise and antioxidant intervention in type 2 diabetic rats, showing both improve blood glucose via hepatic AMPK activation and redox balance, with exercise promoting moderate ROS for AMPK activation.

habCluster identifies geographical boundaries of intraspecific units using a community detection algorithm, showing good alignment with nature reserves for giant pandas.

This study shows that spermine inhibits PAMP-triggered ROS and Ca2+ responses and alters PTI transcription in Arabidopsis.

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

This study identifies and validates novel therapeutic targets for Parkinson's disease by analyzing α-Synuclein self-assembly using foldamers and multiple assays.

This paper identifies an Acidobacterium that produces diverse brGDGTs and shows temperature primarily controls C5-methylation while cyclization is influenced by multiple factors.

The paper shows that cancer-associated fibroblasts transfer ROR2 to gastric cancer cells, activating WNT/PCP signaling and promoting migration.

A comprehensive mutational analysis of the catalytic domain of Arabidopsis CESA6 reveals distinct roles for conserved motifs in CSC vesicle trafficking, protein complex formation, or protein dynamics.

The paper shows that osmotic stress induces stress granule formation in Drosophila S2 cells, modulated by calmodulin and calcium signaling, distinct from Sec body formation.

This paper shows a chemical molecule enhances the differentiation of biliary duct organoids into insulin-secreting cells, improving glucose sensitivity in diabetic mice.

This study identifies alnustone as a drug that inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase A, reducing biofilm formation and protecting against infection.

This study identifies tryptamine, a gut microbiota-derived metabolite, as a contributor to insulin resistance in type 2 diabetes through TAAR1-ERK signaling.

This study shows peramivir reduces cytokine storm by inhibiting NF-κB activity in macrophages and alleviates lung injury in mice.

This study uses molecular dynamics and FRET to analyze PSD-95's conformational dynamics and shows how its flexible structure enables ligand binding.

This paper introduces weighting schemes for quartet-based species tree inference to improve accuracy by reducing the impact of noisy gene trees, outperforming existing methods in simulations and empirical data.

This paper identifies RABL2's role in regulating ciliation by controlling IFT-B1 basal body recruitment and ARL3-mediated BBSome ciliary retrieval through distinct molecular pathways.

This study shows that combining a photolabile Aβ ligand with LED or molecular light can reduce Aβ accumulation in mice, suggesting a new phototherapy approach for Alzheimer's disease.

This paper develops an mRNA vaccine targeting the Omicron variant's RBD, showing it induces Omicron-specific neutralizing antibodies but not against wildtype or Delta strains.

This paper identifies a SARS-CoV-2 neutralizing antibody, ABP-310, that is effective against multiple variants including Omicron and SARS-CoV, suggesting broad therapeutic potential.

This study uses single-cell RNA sequencing to identify five MSC subpopulations, revealing distinct developmental trajectories and functional roles in self-renewal and immunoregulation.

This study identifies a novel gene, srpA, in Streptococcus suis that confers resistance to multiple ribosome-targeting antibiotics by altering ribosome binding.