C. Zhang

This study shows that 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis in models of acute lung injury and sepsis.

This study identifies PIMT as a suppressor of endothelial activation and vascular inflammation by methylating TRAF6, inhibiting its function and reducing ICAM-1 expression.

This paper introduces RPOC, a technology that enables real-time, precise opto-control of chemical processes in live cells with submicron accuracy and nanosecond response time.

This study identifies NSP2-induced repression of Ifnb1 mRNA translation as a mechanism by which SARS-CoV-2 suppresses IFN-β production.

This study investigates the structural basis of SARS-CoV-2 Omicron variant's immune evasion and transmissibility using cryo-EM, revealing conformational changes and enhanced ACE2 binding.

This paper introduces MALPACA, an automated landmarking method that outperforms its single-template counterpart by using multiple templates, and presents a K-means-based approach for template selection.

This study shows anti-ILT3 antibodies block myeloid immunosuppression and enhance tumor killing in solid tumors.

This paper introduces an improved organ explant culture method for Drosophila that enables long-term imaging and gene manipulation, revealing stem cell lineage dynamics in the intestine.

The paper identifies an intermediate state during 2C-like-to-pluripotent state transition using a dual reporter system and finds key regulators involved in this process.

The paper identifies MYB24 as a transcription factor coordinating light-induced terpene and flavonol accumulation in response to anthocyanin depletion in grape berries.

The paper identifies a short prokaryotic argonaute (pAgo) in Sulfolobus islandicus that, along with Aga1 and Aga2, provides antiviral defense through abortive infection.

This study identifies Zfp335 as a transcription factor regulating T cell development by controlling TCRβ expression and cell survival through β-selection-dependent and -independent mechanisms.

This study examines how different taxon-sampling schemes affect Bayesian molecular dating under the unresolved fossilized birth-death process, showing that sampling density impacts divergence-time estimates under certain conditions.

This study investigates how recurrent UTI and estrogen influence the urobiome's taxonomic and functional features in postmenopausal women using metagenomic and metabolomic analyses.

This study shows that humanized mice can be infected by SARS-CoV-2, leading to immune responses and immunopathology, providing a model for studying the virus and testing therapies.

This paper engineers BmoR mutants to create alcohol biosensors with high specificity and sensitivity for detecting specific alcohols in the presence of background ethanol.

This study observes that RNA's twist-stretch coupling reverses from positive to negative with multivalent cations, proposing a unified mechanism for DNA and RNA coupling based on deformation pathways.

This study develops 3D human brown adipose microtissues that improve glucose and insulin homeostasis in obese and diabetic mice.

This study identifies SPRR1 and SPRR2 as antimicrobial proteins produced by sebocytes that defend the skin by disrupting bacterial membranes, showing increased susceptibility to infections in their absence.

The paper develops a computational model to simulate tumor cell plasticity and immune escape after CAR-T therapy, finding that CAR-T stress induces tumor cells to transition into hematopoietic stem-like and myeloid-like cells, leading to relapse.

This study examines how dietary fiber affects gut microbiome dynamics and SCFAs in mice, showing baseline-dependent responses and the importance of ecological modeling.

This study shows that hepatic FGF21 promotes survival during bacterial inflammation by preserving cardiac function, and its signaling via beta-Klotho is required for this protective effect.

This study sequenced Paspalum vaginatum, a stress-tolerant wild relative of maize, and found that inducing trehalose accumulation in maize increases biomass through autophagy.

This study shows that the intracellular glycosyl hydrolase PslG affects signaling, ePsl structure, cyclic-di-GMP levels, and biofilm formation in Pseudomonas aeruginosa.

This study identifies 97 chemical constituents of Jing-Fu-Kang granules and reveals 531 common targets and 136 pathways involved in its mechanism for cervical spondylosis using mass spectrometry and network pharmacology.

This study uses scRNA-seq to compare healthy and fibrotic adult zebrafish liver with human liver, identifying conserved cell identities and fibrosis-related gene expression patterns.

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

This paper reports the cryo-EM structures of NHA2 and reveals its lipid-mediated dimerization mechanism for ion exchange.

The paper shows that gut microbiome dysbiosis in COVID-19 patients is linked to increased risk of bacteremia and microbial translocation.

This paper improves image resolution and signal-to-noise ratio in live cell imaging using a combination of discrete wavelet transform and Lucy-Richardson deconvolution.