D. Zhang

This study identifies a viral protein translation mechanism involving mitochondrial machinery and highlights mitochondria as a target for antiviral drug development.

This study evaluates the immunogenicity of the mRNA vaccine MRT5500 in mice and non-human primates, showing it elicits neutralizing antibodies and TH1-biased responses.

This study identifies two efficient multiplex genome editing tools for Phalaenopsis orchids using a protoplast platform, with DPII-Cpf1 showing the highest editing efficiency.

This study analyzes the transcriptome of potato leaves infected with Alternaria solani to identify gene expression changes and hormone responses associated with disease resistance.

This study identifies Notch1 activation as a key driver of radiation-induced thymic lymphoma in p53 wild-type mice through genomic and functional analyses.

This study shows that eurycomanone promotes lipolysis and reduces fat accumulation by activating the cAMP/PKA pathway in 3T3-L1 cells and C57BL/6J mice.

This study develops a cell-based chimeric vaccine against SARS-CoV-2 that induces strong T cell immunity and neutralizing antibodies without toxicity.

This study shows that repopulating Kupffer cells in adult mice originate directly from hematopoietic stem cells, not from preexisting Kupffer cells or monocytes.

The paper identifies a proto-sex locus in large yellow croaker, showing reduced recombination and dmrt1 expression in testis development and shared functional links between genetic sex determination and environmental sex reversal.

This paper introduces a nonlinear FEM framework in Matlab for analyzing and optimizing bio-inspired compliant mechanisms in medical applications, showing its accuracy through simulations and experiments.

This paper introduces an enzymatic RNA biotinylation method to identify RNA-protein interactions and enrich RNA in mammalian cells, demonstrating its utility in identifying binding partners of 7SK snRNA and HOTAIR.

This study identifies 24 putative ORI events in crustacean mitochondrial genomes, showing that inversion events and gene strand switches can create mutational biases affecting phylogenetic and evolutionary analyses.

This study uses molecular dynamics simulations to show that Remdesivir's 1-cyano group inhibits SARS-CoV-2 RdRp by disrupting nucleotide addition and proofreading, providing insights for drug design.

This paper develops freeze-dried PCR mixes for SARS-CoV-2 detection that can be stored at room temperature, maintaining sensitivity and specificity for up to 28 days.

This paper demonstrates sequential optical activation of two mRNAs in the same cell using photo-cages, enabling precise control of translation with single-cell resolution.

The paper compares immune landscapes in transplant and primary tumors after immunotherapy and radiotherapy, finding that transplant tumors respond better due to CD8+ T cell enrichment.

This study identifies novel Ig domain proteins in SARS-related coronaviruses, highlighting their rapid evolution and potential role in pathogenesis.

This study shows that exosomes from SVV-infected cells can carry and transmit SVV between susceptible and non-susceptible cells, and this transmission is resistant to neutralizing antibodies.

This paper characterizes the kinetics of the radical-mediated C-C bond formation in MoaA, revealing a shunt pathway and determining the rate of the 3',8-cyclization step.

This study identifies adaptive divergence followed by population admixture as a source of additive genetic variance in evolutionarily important traits, showing a strong positive correlation between heritability and evolutionary importance.

The paper identifies CK2 interacting proteins in M. oryzae and shows CK2 correlates with phosphatases and disaggregases, suggesting a role in protein aggregation and RNA/DNA binding.

This study identifies a pathway connecting plasma membrane and chloroplasts that pathogens exploit to suppress salicylic acid-dependent defenses.

This study identifies sex pheromone plasmids as a mechanism for disseminating linezolid-resistance in E. faecalis through plasmid transfer.

This paper improves pulcherriminic acid production in Bacillus licheniformis through multistep metabolic engineering, achieving a record yield of 556.1 mg/L.

This study shows that germline RNA helicases regulate P granule formation and disassembly through RNA binding and release, with FGG repeats promoting perinuclear localization, and links defects in this process to fertility issues in C. elegans.

This paper demonstrates an enzyme-free method to synthesize natural phospholipids in water, forming cell-like membranes and establishing proton gradients.

The paper shows Ctf4 organizes sister replisomes and Pol alpha into a replication factory by dimerizing CMG helicase and binding one Pol-primase.

The paper describes a hybrid DNA structure combining G-quadruplex and i-motif elements, revealing new structural diversity in DNA.

The paper reports the cryo-EM structure of the eukaryotic CMG helicase on forked DNA, revealing a 'dam-and-diversion tunnel' mechanism for DNA unwinding.