E. O'Neill

Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity

The paper shows that ionizing radiation enhances immunotherapy in pancreatic cancer by increasing tissue-resident NK cells that support CD8 T cell activity through cDC1-dependent mechanisms.

Metabolic reprogramming and flux to cell envelope precursors in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics

This study shows that mutating the pentose phosphate pathway gene pgl in MRSA increases resistance to beta-lactam antibiotics through metabolic reprogramming and changes in cell envelope precursors.

Systems modelling of TGF-β/Hippo signalling crosstalk uncovers molecular switches that coordinate YAP transcriptional complexes

This study uses systems modelling to uncover molecular switches that control YAP transcriptional complexes, revealing how RASSF1A and ITCH regulate context-dependent YAP function.

53BP1 mediated recruitment of RASSF1A at ribosomal DNA breaks facilitates local ATM signal amplification

The paper identifies RASSF1A's role in recruiting at rDNA breaks to amplify ATM signals and maintain genome stability, showing its loss leads to DNA damage and reduced cell viability.

A lack of repeatability creates the illusion of a trade-off between basal and plastic cold tolerance.

The paper tests the thermotolerance-plasticity trade-off hypothesis in Drosophila melanogaster and finds that apparent correlations are due to regression to the mean, not physiological constraints.

RASSF1C oncogene elicits amoeboid invasion, cancer stemness and invasive EVs via a novel SRC/Rho axis

This study shows RASSF1C promotes amoeboid invasion, cancer stemness, and invasive extracellular vesicles through SRC/Rho axis activation in breast cancer.

TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes

This study identifies TET2-driven 5hmc loss at GATA6 as a mechanism defining PDAC transcriptional subtypes and shows that TET2 stabilization with Metformin and Vitamin C reverses squamous-like tumor features.

Impaired alanine transport or exposure to D-cycloserine increases the susceptibility of MRSA to beta-lactam antibiotics

The paper shows that impairing alanine transport or exposing MRSA to D-cycloserine increases susceptibility to beta-lactam antibiotics by reducing peptidoglycan crosslinking.

RASSF1A Is Required For The Maintenance Of Nuclear Actin Levels

This study identifies RASSF1A as a regulator of nuclear actin levels by supporting exportin-6 binding to RAN GTPase, linking it to tumor suppression through MRTF/SRF regulation.

Hippo Pathway Deregulation Drives Tissue Stiffness and Cancer Stem-like Cells in Lung Adenocarcinoma

This study shows that epigenetic silencing of RASSF1A and increased P4HA2 activity drive tissue stiffness and cancer stem-like properties in lung adenocarcinoma, with potential therapeutic implications.