H. Kim

This study identifies that Trm10 substrate recognition depends on tRNA conformational changes induced by the enzyme, revealing a novel mechanism for tRNA modification.

This study tests mucoactive drugs that enhance mucociliary clearance and finds three inhibit SARS-CoV-2 replication in human airway epithelial cells by improving ciliary function and redox state.

This study generates insulin-secreting organoids from human gastric stem cells that restore glucose homeostasis in diabetic mice.

IMPASTO enables erasureless cyclic imaging for multiplexed spatial proteomics through self-supervised neural unmixing, achieving 30-plex imaging with reduced tissue distortion.

This paper introduces a vortex ultrasound technique for endovascular sonothrombolysis that significantly improves clot lysis rates in cerebral venous sinus thrombosis.

This paper demonstrates that deglycosylated KKO (DGKKO) can prevent and reverse thrombocytopenia and thrombosis in a HIT murine model.

The paper introduces a chemoproteomics method to identify heme-binding proteins, revealing new roles for heme in chromatin remodeling, DNA repair, RNA splicing, and vesicular trafficking.

This paper develops a live cell lineage tracing method to track dormant cancer cells in vitro, revealing that dormancy is influenced by both intrinsic and extrinsic factors.

This study shows SARS-CoV-2 variants with P323L or P323L/G671S mutations in NSP12 have enhanced polymerase activity at 33°C and higher transmissibility in ferrets.

This study identifies NR2F6 as a melanoma-intrinsic regulator of anti-tumor immunity, showing that its inhibition enhances immunotherapy response and tumor suppression.

The paper measures working strokes from curling protofilaments at disassembling microtubule tips, showing magnesium and species differences affect mechanical energy output.

This study investigates how compression affects multi-bilayer lipid films, showing structural and mechanical changes at multiple scales, including nanoscale undulations and buckling delamination.

This paper introduces a microfluidic dielectrophoresis method to rapidly distinguish E. coli with different LPS structures by analyzing electrokinetic properties.

The paper identifies MAIT cells as immunosuppressive in glioblastoma, correlating their presence with poor patient survival and immune suppressive gene upregulation.

The paper develops Per1-luc and Per2-luc reporter cell lines to study circadian mechanisms and uncover differences between Per and Cry paralogs.

This study shows that EWSR1 prevents aneuploidy by regulating Aurora B localization at inner centromeres through its interaction with Aurora B.

This study shows that glioblastoma cells use autophagosomes in migrasomes to relieve stress and prevent cell death by inhibiting autophagosome/lysosome fusion.

This study shows that enterovirus genome recombination depends on eIF2A/eIF2D-dependent translation, not IRES-mediated translation, and explains non-replicative recombination and RNA persistence.

The paper identifies effector recognition specificities of NbPtr1 and NbZAR1 in N. benthamiana and shows their distinct and overlapping roles in detecting bacterial effectors.

This study identifies a conserved DNA binding motif in SDE2 that extends beyond the canonical SAP domain, enhancing ssDNA binding and replication fork stability.

This study shows that inhibiting 5-lipoxygenase with malotilate prevents skeletal muscle atrophy by enhancing organogenesis signaling and insulin-like growth factor-1 expression.

The paper identifies phospho-sites in huntingtin, showing PKA phosphorylation of Ser2550 in the C-HEAT domain accelerates its degradation.

This study identifies CRISIS2, an RxLR effector from Phytophthora capsici, which suppresses plant immunity by interacting with PMA and BAK1, leading to cell death and enhanced pathogen virulence.

The paper generates a high-quality little skate genome and analyzes motor neuron gene regulation across species to identify conserved and divergent mechanisms in vertebrate locomotion evolution.

This study identifies Anoctamin 9 as essential for mammalian olfaction, showing its role in amplifying olfactory signals and linking its downregulation to Covid-19-associated anosmia.

This paper develops a mosaic nanoparticle vaccine, 6RBD-np, that induces full protection against SARS-CoV-2 wild type and Delta variants in mice.

This study investigates MCT deficiency in Syrian hamsters infected with SARS-CoV-2, finding a 67% reduction in MCT rate by 2 dpi due to decreased motile ciliation.

This study investigates the role of H3K14ac and associated proteins in PARPi resistance in HGSOC, finding that BRPF3 knockdown reduces resistance while HBO1 inhibition does not.

This study identifies acoustic and postural displays in Danionella dracula during aggressive interactions, showing differences based on residency and body size.

This study investigates monaural and binaural masking release using speech-like stimuli and finds no significant comodulation masking release but comparable binaural masking level difference to prior results.