H. Kim

This study shows that BHMT deletion in mice leads to homocysteine-induced ER stress and CREBH activation, increasing FGF21 which causes adipose browning and atrophy.

The paper enhances CRISPR-Cas12a system specificity and efficiency using a chimeric DNA-RNA guide, achieving 7.41 and 7.60 times improvements respectively.

This paper demonstrates that parylene coating makes 3D printed microdevices biocompatible and suitable for elastomeric device fabrication, enabling long-term cell viability and diverse device casting.

The paper uses scRNA-seq to identify cell populations in Nicotiana attenuata petals and uncover the biosynthetic pathway of benzylacetone.

The paper develops a hydrogel-based microplate to study bacterial responses to spatial nutrient gradients from algae, showing taxon-specific community development influenced by nutrient availability.

This paper evaluates CDCP1 as a target for radioligand therapy in mCRPC, showing its expression in most biopsies and demonstrating antitumor effects with 177Lu-4A06.

The paper performs a multi-omics meta-analysis of microbial and metabolite data from diverse environments, revealing patterns of diversity and co-occurrence across biomes.

This study expands prime editing by linking reverse transcriptase to FnCas9(H969A) nickase, enabling more precise and extended target gene modifications.

The paper shows that mammary epithelial lineage determines HR and PARP inhibitor vulnerability, with luminal cells having high-fidelity HR and PARPi sensitivity.

This study analyzes longitudinal glioma data to identify recurrence-associated changes in genetics and microenvironment linked to therapy resistance.

The paper identifies germline variants associated with the tumor immune microenvironment, linking them to cancer risk and immunotherapy response.

This study examines how substrate stiffness affects barrier function in iPSC-derived BBB endothelial-like cells, finding enhanced TEER on compliant substrates and no effect on P-glycoprotein activity.

This study identifies ERELEE4 as an ORA59-binding cis-element and shows ORA59 regulates JA/ET-responsive genes through direct promoter binding, with differential preference for GCC box and ERELEE4 based on hormone activation.

The paper computationally designs and improves a protein binder targeting HER2 domain IV, achieving a two-orders-of-magnitude increase in binding affinity through iterative computational and experimental feedback.

This paper reveals that Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome through H2O2-mediated control of GAPDH activity.

This study analyzes the blood microbiome in a porcine model of fecal-induced peritonitis, finding stable bacterial populations and taxonomic differences between fecal and blood microbiomes.

The paper investigates the role of Spc1 in yeast, showing it shields transmembrane segments from signal peptidase cleavage, thereby influencing substrate selection.

The paper identifies synergistic genetic targets in Ph-like B-ALL using network analysis to guide combination therapy, showing improved efficacy in preclinical models.

This study identifies transcriptome changes in Chlorella sp. HS2 under high salinity stress, revealing lipid accumulation and halotolerance mechanisms through carbon reallocation and NADPH co-factor regulation.

This paper develops a platform for remote biochemical monitoring using microparticle-based biosensors and OCT, enhanced by deep learning for 3D time series data analysis.

The paper identifies therapeutic genetic variations in Hsp104 homologs that specifically counter proteotoxicity in yeast, human cells, and C. elegans by enhancing passive chaperone activity.

This study identifies cholesterol's essential role in SARS-CoV-2 membrane fusion and syncytia formation, suggesting statins may benefit COVID-19 patients.

This study develops human spinal cord-like organoids (hSCOs) to enable quantitative drug screening for neural tube defects.

This study evaluates compounds targeting SARS-CoV-2 proteases Mpro and PLpro, finding limited efficacy for Mpro due to off-target inhibition of host cathepsins and no viable hits for PLpro.

This paper introduces a self-sterilizing PPE material that deactivates SARS-CoV-2 in 30 seconds, outperforming conventional copper configurations.

This study encodes multiple virtual signals in DNA barcodes using single-molecule FRET, enabling the differentiation of six barcodes without sequence exchange.

The paper uses live-cell imaging to show uneven ecDNA segregation and transcriptional clustering in cancer cells, explaining ecDNA accumulation and oncogenesis.

The paper shows that the plant NLR CCA309 targets P-type ATPase to cause membrane depolarization, calcium influx, and cell death during hypersensitive response.

This paper identifies TgSPY as the O-fucosyltransferase in Toxoplasma gondii, showing it modifies proteins but is not essential for growth, yet affects protein levels and virulence in mice.

This study established tonsil epithelial cell-derived organoids and demonstrated their feasibility as an ex vivo model for SARS-CoV-2 infection.