H. Li

The paper shows mutant KRAS induces T cells to become immune-suppressive Treg-like cells through exosomes, sera, or direct transfection, with single-cell sequencing identifying the interferon pathway as the mechanism.

This study shows IL-10 promotes wound healing by recruiting endothelial progenitor cells through STAT3-dependent regulation of VEGF and SDF-1 in both control and diabetic wounds.

This study evaluates how different storage conditions, preservation periods, and sequencing platforms affect gut microbiome profiles using 16S rRNA gene sequencing.

This study tests if inhibiting microbial beta-glucuronidase prevents breast cancer in MMTV-PyMT mice, finding no significant effect on tumor formation or markers.

The paper shows Ctf4 organizes sister replisomes and Pol alpha into a replication factory by dimerizing CMG helicase and binding one Pol-primase.

This study identifies convergent genomic signatures of high altitude adaptation in domestic mammals by analyzing 327 genomes, revealing positive selection in genes like EPAS1 and C10orf67.

This paper introduces AbMap, a high-throughput epitope mapping technology that identifies epitopes for over 200 antibodies in a single run, including 14 anti-PD-1 antibodies.

The paper reports the cryo-EM structure of the eukaryotic CMG helicase on forked DNA, revealing a 'dam-and-diversion tunnel' mechanism for DNA unwinding.

This study examines how melatonin affects wheat seed germination and amino acid content under PEG stress, finding that 300 μM melatonin improves germination metrics and lysine levels.

This study identifies G-CSF as a metabolic niche factor that replenishes Pax7Hi muscle stem cells in aged mice through exercise-induced mechanisms.

This study investigates the antifungal activity and mechanisms of a novel olive tree defensin against multiple ascomycete pathogens.

This study shows that FXR agonists reduce bacterial translocation in cirrhosis by stabilizing the gut-vascular barrier and mucus layer.

The paper develops a low-cost automated imaging platform for malaria diagnosis, achieving high sensitivity and specificity in parasitemia quantification.

This study compares microbiome composition between gut and fecal samples from aquatic vertebrates, showing that sample type and preservation methods significantly affect results.

This study identifies a novel O_SCPCAPLC_SCPCAP-serine exporter, SerE, and its positive regulator NCgl0581 in C. glutamicum, showing their roles in amino acid export and transcriptional regulation.

The paper shows CD38 expression in immune infiltrates predicts response to anti-PD-1 immunotherapy in HCC patients.

This study shows the photoactive site in GtACR1 affects chloride conductance and channel closing through electrostatic changes and distance-dependent effects.

This study shows that benzoate-tolerant E. coli strains lose MDR efflux pumps, hydrogenases, and the Gad regulon while upregulating porins, leading to increased antibiotic sensitivity.

This study shows that climate change has caused a northward shift in the range of wheat pests, leading to increased crop damage despite pesticide use.

Scale-free vertical tracking microscopy captures untethered behavioral dynamics at cellular resolution for marine plankton.

This paper introduces a method to remotely control CRISPR-dCas9 activity using heat, allowing dynamic transcriptional modulation in mammalian cells.

The paper identifies subcellular processes involved in cannabinoid-1 receptor regulated neurite outgrowth and shows they are distributed and deep.

This paper introduces a gradient two-photon microscopy technique that enables rapid volumetric imaging with reduced phototoxicity by using two axially gradient excitation beams.

The paper shows OxyR in E. coli detects reactive sulfane sulfur and activates genes for its removal via thioredoxin and glutaredoxin.

This study shows that SCFAs from gut microbiota stimulate GLP-1 secretion in chickens, which suppresses hepatic lipogenesis.

The paper introduces a new metric, AFTIR, to guide monoclonal antibody dose selection by simplifying complex target-mediated drug disposition models into four key parameters.

This study shows that knocking down DGKZ in HL-60 cells induces apoptosis and G2/M phase arrest via the caspases pathway.

This study identifies βVPE as a key enzyme in Arabidopsis thaliana that activates proproteases for tapetal degradation and pollen development.

The paper investigates the Prp8 intein in Cryptococcus neoformans, showing that copper and zinc inhibit intein splicing through distinct mechanisms, potentially affecting spliceosome function.

This study identifies 6-phosphogluconate dehydrogenase (PGD) as essential for ER structural integrity and protein secretion, linking cytosolic carbohydrate metabolism to ECM secretion processes.