H. M. Lai

COLOR-3D: a versatile tool for revealing novel 3D histological features

COLOR-3D improves 3D histology by enhancing dye penetration and enables quantitative analysis of tissue morphology and aging-related changes in mouse liver.

nELAVL phosphorylation by CDKL5 regulates RNA metabolism and condensates communication to promote experience-dependent maturation of the visual cortex

This study identifies CDKL5-mediated phosphorylation of nELAVL as critical for regulating RNA metabolism and condensate communication, essential for visual cortex maturation.

Universal nucleic acid preservation in biological fluids with boron clusters

This paper introduces [B12H12]2- as a broad-spectrum nuclease inhibitor that preserves nucleic acids in biological fluids at room temperature for extended periods.

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks

This study shows psilocybin alters large-scale cortical network connectivity in mice by strengthening inputs from perceptual and medial regions and weakening cortico-cortical loops, dependent on drug-evoked spiking activity.

Cerebellum-Targeted Transcranial Focused Ultrasound Stimulation Modulates Hippocampus Neural Activities

This study shows that cerebellum-targeted tFUS at 10kHz modulates hippocampal neural activity through cerebellum cortex, not deep nuclei, via altered neurodynamic interactions.

INSIHGT: Accessible multimodal systems biology with quantitative molecular phenotyping in 3D

The paper introduces INSIHGT, a 3D spatial biology method for multi-modal molecular phenotyping, and demonstrates its application in mapping cellular structures and identifying novel cell types in human and mouse tissues.

Topologically distinct and equivalent multiple efferent arterioles in the human glomeruli

The paper demonstrates the existence of multiple efferent arterioles in human glomeruli using 3D imaging and graph analysis, showing their topological distinctness or equivalence and their role in blood flow redistribution.

Three-dimensional visualization of blood vessels in human gliomas based on tissue clearing and deep learning

This study combines tissue clearing and deep learning to create 3D visualizations of human glioma vasculature, revealing vascular differences between low-grade and high-grade gliomas.

A neural circuit basis for binasal input-enhanced chemosensory avoidance

This study investigates how larval zebrafish integrate binasal chemosensory inputs to guide avoidance behavior using microfluidics and brainwide imaging.

Genome-wide reversal of glial and neurovascular cell transcriptomic aging signatures by GLP-1R agonism

This study shows GLP-1R agonism reverses transcriptomic aging in brain cells and reduces AD-associated signatures in microglia.

Zonation-dependent single-endothelial cell transcriptomic changes in the aged brain

This study identifies zonation-dependent transcriptomic changes in aged brain endothelial cells, highlighting functional impacts on the BBB and AD-associated genes, and shows reversal with GLP-1R agonist treatment.