H. Yang

The paper investigates whether apparent signals of positive selection in DNA sequences are actually due to relaxed negative selection, finding strong fluctuations in negative selection strength across species.

This study maps 3D genome organization in normal and AML haematopoietic stem cells, finding increased chromatin loops to oncogenes in AML and identifying MEIS1 and HOXA9 as key oncogenes regulated by these interactions.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.

The paper characterizes site-specific N-glycosylation of SARS-CoV-2 spike proteins expressed in human and insect cells, revealing differences in glycan types and their implications for infection and vaccine development.

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

This paper develops a sensitive and reusable method for detecting Exo III activity using DNB nanoarrays and cPAS sequencing technology, showing a linear response in low concentration ranges.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

This paper introduces a NIR-II cell tracker for real-time monitoring of stem cell behavior in vivo, revealing differential responses to diseased environments and enabling long-term tracking beyond 30 days.

The paper develops interpretable deep learning models to search for similar disease states across social media and PubMed using histopathology images and clinical data, achieving high precision in real-time diagnosis assistance.

This study investigates the transcriptomic response of Caenorhabditis elegans to acidic stress environments, identifying two major pathways involved in cuticle synthesis and xenobiotic metabolism.

This study investigates the PK/PD relationship of tilmicosin against M. hyopneumoniae, identifies resistance mechanisms, and suggests optimal dosing regimens.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

The paper identifies a germline non-coding GATA3 variant that alters chromatin topology and contributes to Ph-like ALL by activating an enhancer and reshaping 3D genome organization.

The paper introduces DPSN, a database that standardizes short names of amplicon-sequencing primers to reduce ambiguity and improve communication.

The paper creates a high-resolution global root biomass map using field measurements and environmental data, finding lower root biomass than previous studies due to improved methods and data.

The paper shows fibroblasts protect B. burgdorferi from a drug combination, but oregano or carvacrol essential oil enhances drug efficacy against the bacteria in fibroblasts.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

The paper assembles over 56,000 metagenome-assembled genomes from oral microbiome samples, revealing new taxa and biomarkers for diseases.

This study identifies recurrent mutations and copy number variations as key drivers of metastasis in treatment-naive breast cancer using pre-clinical mouse models.

The paper uses historical and paleoecological data from Gatun Lake to study long-term impacts of damming and other stressors on tropical river ecosystems.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

This study shows BRD2 and SREBP2 work together to increase sigma-2 receptor expression when cells lack cytosolic cholesterol.

The paper estimates that 57% of mammalian genes are under purifying selection for stop codon preference, with UGA codons being more conserved and associated with specific gene characteristics.

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.

This study develops an efficient CRISPR/Cas9 method for integrating a large transgene cassette into the CEP112 locus in pigs, achieving successful expression of microbial enzymes in salivary glands.

This paper demonstrates that expressing eight immunomodulatory genes in mouse embryonic stem cells enables them to avoid immune rejection and form immune-privileged tissues in allogeneic hosts.

The paper shows that 3D matrix stiffness and dimensionality influence the expansion of hematopoietic stem and progenitor cells in vitro, affecting lineage fractions and gene expression.

This study identifies TMEM16F as a phospholipid scramblase essential for trophoblast fusion and placental development by externalizing phosphatidylserine.