H. Yang

The paper compares metatranscriptomic responses of Arabidopsis to endophytic and pathogenic Fusarium strains, revealing transcriptional plasticity and differential gene regulation.

This study shows SARS-CoV-2 entry into host cells relies on clathrin-mediated endocytosis and phosphoinositides, with ACE2's cytoplasmic domain and enzymatic activity not required for this process.

This study shows that RIPK3 phosphorylation at S165/T166 switches its function from necroptosis to apoptosis, driving corpus luteum regression via PGF2-induced apoptosis.

The paper develops an RNA editing signature (GCRE) to predict chemotherapy response in gastric cancer, achieving 84% accuracy and showing better outcomes in patients with higher editing levels.

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

The paper demonstrates that HLA-E restricted, HIV-1 specific CD8+ T cells can suppress HIV-1 replication in vitro, suggesting potential for a universal vaccine.

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

This study uses single-cell RNA-sequencing to analyze prostate cancer tumor microenvironment, identifying heterogeneous epithelial cell states and tumor-associated club cells.

The paper shows that knocking down LC3 increases micronuclei by promoting mitochondria-to-micronuclei transition during nuclear development.

The paper identifies sex-biased ZRSR2 mutations in BPDCN that impair pDC activation and apoptosis, linking X chromosome mutations to male-predominant leukemia.

This paper identifies a mammalian-unique eIF4E2-GSK3β pathway that prevents senescence and protects against hypoxia by maintaining p53 phosphorylation.

This study shows arachidonic acid metabolism regulates macrophage polarization by affecting oxidative phosphorylation through PPARG, influencing M1 and M2 macrophage activation.

This study synthesizes and characterizes SR-A3, a stereoisomer of a natural product, showing enhanced binding kinetics and therapeutic efficacy in a mouse lymphoma model.

The paper shows mitochondria fragment and reassemble to form nuclei and intranuclear inclusions during nuclear development.

This study shows telmisartan enhances insulin secretion via ion channels, independent of AT1 receptor and PPARγ, in rat islets and diabetic mice.

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

This study examines the effects of different dietary protein levels on ewe growth, serum biochemistry, and lamb development during late pregnancy, finding no significant impact on growth performance but significant effects on metabolic indicators and lamb body measurements.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This paper shows HCMV drives WDR5 to the virion assembly compartment to facilitate virion assembly, expanding its role beyond nuclear egress.

This study identifies site-specific O-glycosylation patterns in SARS-CoV-2 spike proteins, revealing host-dependent variations and their potential implications for viral function and therapeutic development.

The paper identifies the long noncoding RNA LOUP as a mediator of RUNX1 and RUNX1-ETO effects in t(8;21) AML, showing it promotes myeloid differentiation and inhibits cell growth by regulating PU.1 expression.

This study examines IgG and memory B cell responses to SARS-CoV-2 infection, finding broad reactivity to the S2 subunit and durable B cell immunity.

This study identifies a mechanism by which pseudogene 5 induces DNA demethylation and reactivates the oncogene SALL4 in hepatocellular carcinoma, linking HBV infection to HCC progression.

This paper develops a DNA-based nanosensor to detect acetylcholine in living mice, showing sensitive detection and spatial resolution of ACh transmission in the peripheral nervous system.

This study compares clonal evolution across right-sided colon cancer, left-sided colon cancer, and rectal cancer patients, finding differences in evolutionary patterns and identifying polyclonal origins of lymph node and extranodal tumor deposits.

This study assesses the effectiveness of riverine water eDNA for monitoring aquatic and riparian biodiversity, finding it effective for detecting species and bioinformation in specific conditions.

The study tracks vagino-cervical microbiome changes in 60 women over a year after oral probiotics, finding no colonization but stability in Lactobacillus-dominated communities and potential benefits for some individuals.

The paper tests the Red Queen hypothesis by analyzing two Drosophila de novo miRNAs, finding their fitness contributions vary between species, supporting their different evolutionary fates.