H. Zhao

The paper identifies a novel MCR-1 variant with low β-lactam co-resistance and shows synthetic peptides from this variant have broad-spectrum antimicrobial activity.

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

The paper shows degenerated CRISPRs encode regulatory RNAs that autoregulate Cas protein expression, balancing immunity and host fitness costs.

The paper evaluates deep learning methods for molecular conformation generation by comparing them to a stochastic 'infinite physical monkey' approach, finding that the monkey method outperforms most DL-based methods in coverage and docking success.

The paper identifies a new class of ribosomal peptides, daptides, with two amino termini, discovered through genome mining and characterized experimentally.

This paper introduces VECTOR, a method using light-inducible condensates to reposition DNA loci and measure chromatin viscoelasticity.

This study shows that ACE2 binding blocks RBD antigenicity, reducing neutralizing antibody production, and suggests improving vaccine efficacy by exposing RBD immunogenicity.

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

The paper presents the Cryo-EM structure of DNA polymerase θ helicase domain with and without inhibitor novobiocin, revealing a non-canonical binding pocket and insights into its mechanism.

This study shows AmotL2 regulates YAP promoter accessibility through chromatin remodeling in endothelial cells under mechanical stress.

This study modifies human tendon stem cells to enhance graft ligamentation and tendon-bone healing after ACL reconstruction, showing improved recovery in animal models.

This study identifies distinct interactions of GEMC1 and MCIDAS with SWI/SNF subcomplexes in multiciliated cell differentiation and shows that these interactions are required for MCC-specific transcriptional regulation.

This paper develops an mRNA vaccine for chronic hepatitis B that shows strong immunogenicity and persistent virological suppression in mouse models.

This study identifies fibronectin oxidation by lysyl-oxidase enzymes as a force-independent nucleation step initiating fibrillogenesis, which is critical for cell adhesion and mechanosensing.

The paper uses molecular dynamics and AI to show eukaryotic histones can form stable homodimers, with disordered tails favoring heterotypic dimers.

This study evaluates the combined developmental toxicity of cyhalofop-butyl and quizalofop-p-ethyl on zebrafish embryos, finding an antagonistic effect and altered gene expression related to apoptosis and cardiac development.

This study shows that MFN2 deficiency leads to increased cytosolic Ca2+ and overactivation of RhoA and non-muscle myosin II, causing atypical peripheral actin band formation in mouse embryonic fibroblasts.

This paper develops a super DNA-enzyme molecule (SDEM) that enables on-demand enzyme activity modulation with improved detection limits and reaction rates compared to free enzymes.

This study determines the cryo-EM structure of SLC19A1 and identifies key residues and coupled substrates for folate recognition.

This study analyzes the genome of eastern oysters to reveal genetic diversity, selection pressures, and human impacts across populations.

The paper reports the Cryo-EM structure of active GPR75 with a nanobody, revealing its activation mechanism and providing a structural basis for anti-obesity drug discovery.

Matrix-seq provides a microfluidic barcoding method for adjustable-resolution spatial transcriptomics, reducing technical barriers and enabling application in multiple biological fields.

This paper develops an engineered sBCMA-Fc fusion protein with enhanced binding affinity to APRIL and BAFF, showing improved antitumor activity against multiple myeloma and diffuse large B cell lymphoma in preclinical models.

The paper generates and analyzes an mcr-1 mutant library to assess the impact of mutations on colistin resistance, finding that most mutations in the catalytic domain reduce resistance.

This paper updates the classification of subkingdom Mucoromyceta by introducing two new phyla, five new orders, six new families, and 73 new species, along with estimated divergence times.

The paper shows that aging-related iron accumulation reduces estrogen receptor expression, diminishing the benefits of hormone replacement therapy in late postmenopausal women with atherosclerosis.

This study identifies OsAIM1 as essential for high basal SA levels in rice, which regulate stomatal aperture and shoot temperature.