H. Zhou

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

The paper reports the crystal structure of SARS-CoV-2 main protease bound to shikonin, revealing conformational changes and binding modes that could inform drug design.

The paper uses scRNA-seq to compare ACE2 expression and bladder cell clusters in OAB and healthy mice, finding reduced umbrella cells and higher ACE2 in epithelial cells, suggesting altered 2019-nCoV infection pathways.

This study shows swine ANP32A supports avian influenza polymerase activity, and human-adapted viruses evolved to use human ANP32 proteins more efficiently.

This study shows that microbubble-mediated cavitation induces apoptosis and reduces invasion in AsPC-1 cancer cells through increased calcium, cleaved Caspase-3, BAX, and decreased Bcl-2, HIF-1, and Vimentin.

The paper examines how C4 grasses optimize and reorganize photosynthetic properties through optimality modeling, physiological measurements, and phylogenetic analysis, finding higher Jmax/Vcmax ratios and ongoing optimization processes.

This study examines how C4 photosynthesis evolution affects hydraulic traits in grasses, finding that younger C4 lineages have higher hydraulic conductance and capacitance, while older lineages show reduced values.

This study identifies OsVST1 in rice and its homologs in Arabidopsis as regulators of root system architecture, showing conserved function and potential for agricultural optimization.

The paper reports the structure of SARS-CoV-2 main protease in the apo state at physiological pH, revealing its inactive conformation and structural differences from the active state.

The paper evaluates the antiviral efficacy of Pyramax(R), a malaria treatment, against Ebola virus and finds its components act additively to inhibit infection.

This study shows that CREB1 regulates colorectal cancer cell plasticity by controlling lncRNA CCAT1 and the NF-κB pathway through interactions with CBP/p300 and p65.

This study introduces Aspergillus fumigatus α-1,2-mannosidase MsdS into Trichoderma reesei, altering N-glycan processing and improving lignocellulose degradation while causing abnormal polarity and secretion phenotypes.

The paper develops an interpretable machine learning framework to identify gut microbiome features predictive of type 2 diabetes, validated across multiple cohorts and linked to metabolic outcomes.

This study identifies AfRip3 as a key modulator of necroptotic death in A. fumigatus, showing it is induced by Ca2+ and activates JNK and SMase pathways.

This paper evaluates pyronaridine tetraphosphate's efficacy against Ebola and Marburg viruses in guinea pigs, showing 40% survival and suggesting its potential for antiviral repurposing.

This study shows that HBV infection enhances the hexosamine biosynthesis pathway, leading to O-GlcNAcylation of SAMHD1, which boosts antiviral immunity against HBV and HIV-1.

This paper identifies a novel bat coronavirus, RmYN02, with sequence similarities to HCoV-19 and natural insertions at the S1/S2 cleavage site, suggesting a possible recombinant origin for HCoV-19.

The paper identifies four metabolites that reduce Staphylococcus aureus bloodstream infection by inhibiting arginase and enhancing phagocytic killing through a nitric oxide-dependent mechanism.

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

This study shows artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression by enhancing autophagy and modulating NF-κB activity.

The paper determines the crystal structure of the 2019-nCoV spike RBD bound to ACE2, revealing structural similarities to SARS-CoV and insights into antibody epitopes.

This study shows that mitochondrial respiration via PDH controls the speed of muscle stem cell activation, which declines with age, and that restoring PDH activity can improve muscle regeneration in aged mice.

The paper introduces a microtubule probe that enables correlative super-resolution fluorescence and electron microscopy to study microtubule ultrastructure.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

The paper reports the structure of arrestin-2 bound to neurotensin receptor 1, revealing a novel orientation that enables coupling to GPCRs lacking a C-terminal tail.

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

This study investigates changes in mechanical properties and nanomorphology of BMSCs during early apoptosis using AFM and other techniques, finding that mechanical damage precedes apoptotic signals.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

The paper compares subgenome asymmetry in artificial and natural allopolyploid genotypes, finding that variable genome components influence subgenome differences and suggest their consideration in polyploid evolution studies.

This study examines gut microbiome differences between lung cancer patients and healthy individuals, finding altered microbial composition but unclear links to cancer development.