J. Chen

The study examines enzyme activities and microbial nutrient limitation across soil depths in subtropical forests, finding co-limitation by C and P rather than N.

The paper introduces DPSN, a database that standardizes short names of amplicon-sequencing primers to reduce ambiguity and improve communication.

This study investigates HMGB1's role in invasive C. albicans infection and shows that EP reduces HMGB1 levels, tissue damage, and mortality in infected mice.

This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.

This paper develops an anti-MUC1 antibody-drug conjugate targeting a GSTA glycosite-signature epitope, showing potent antitumoral efficacy and low toxicity in NSCLC models.

The paper creates an in situ atlas of mitochondrial DNA in mammalian tissues, revealing higher mtDNA content in stem/progenitor cells and age-related decreases in renal tubules.

This study shows that positional isomers of a synthetic non-nucleoside triphosphate can differentially control myosin function by altering force and motion generation without changing myosin structure.

This study shows CPR5 regulates ethylene signaling by interacting with ETR1's N-terminal domains and controlling mRNA nucleocytoplasmic transport.

The paper develops a thermodynamic model to predict minimum free energy requirements for sulfate reduction and methanogenesis in synthetic microbial communities using experimental data.

This study identifies amyloid beta as a factor secreted by melanoma cells that suppresses neuroinflammation and promotes brain metastasis.

This study evaluates the optimal storage temperature for Ponkan mandarins using PCA, finding that 10°C best preserves quality and reduces oxidative stress.

The paper tests the Nearly Neutral Theory by analyzing genomic data from 59 species, finding that both effective population size and beneficial mutations influence the proportion of effectively neutral mutations.

The paper identifies fibroblast-expressed PIK3Cδ as a key driver of triple-negative breast cancer progression through paracrine signaling and shows its prognostic significance.

This paper investigates the structural mechanism of regioselectivity in a bacterial acyl-CoA dehydrogenase, identifying key residues and structural features responsible for its unique substrate specificity.

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

This study compares empathic responses in male and female mice and rats, finding no species difference in empathic behaviors but notable sex differences in mice.

This study evaluates how adding Chinese herbal medicine residues affects antibiotic resistance genes and bacterial communities in chicken manure composting, finding increased ARG removal with higher residue addition.

This paper develops a CRISPR-Cas12a-based system for rapid, sensitive, and specific ASFV detection without nucleic acid amplification, achieving a detection limit of 100 fM.

This study uses single-cell RNA sequencing to analyze gastric cancer tumor microenvironment, identifying reprogramming in immune and stromal cells and novel molecular targets for immunotherapy.

This study shows that silver ions increase the diffusive motion of H-NS proteins in live bacteria by weakening their DNA binding through DNA dehybridization.

This paper identifies a jasmonic acid regulatory module controlling spikelet fertility in sorghum, showing that mutations in MSD1 and MSD2 increase grain number per panicle.

This study shows H. pylori infection inhibits autophagy, leading to DNA damage via p62-mediated Rad51 ubiquitination in gastric cells.

This study shows that HA-MAP hydrogel injection reduces cerebral atrophy and promotes pro-repair astrocyte and axonal infiltration after ischemic stroke.

The paper introduces a female ESC system called Xmas that identifies the BAF complex as essential for X chromosome inactivation.

This study identifies LncRNA MIR4435-2HG as a mediator of cisplatin resistance in HCT116 cells via the Nrf2/HO-1 pathway.

This study shows TraR regulates transcription by altering RNAP conformation and dynamics, affecting promoter DNA interactions and transcription outcomes.

This study develops polygenic risk scores for cardio-renal-metabolic diseases in the Penn Medicine Biobank and finds limited predictive value in African ancestry individuals.

This paper develops a method to generate and activate recombinant mammalian selenoproteins using genetic code expansion with photocaged selenocysteine, bypassing SECIS elements and selenium dependency.

This study identifies C17orf53 as a novel gene involved in inter-strand crosslink repair, showing its role in DNA replication and repair factor loading.

This study shows Nrf1 represses tumor growth by inhibiting Wnt/β-catenin signaling and other pathways through ubiquitination of β-catenin and regulation of key genes.