J. Chen

This study shows that estradiol and leptin modulate gut microbiota in female ob/ob mice on a high-fat diet, with E2 reducing microbial diversity and altering specific taxa.

The paper identifies genome-wide SNPs and InDels in four Actinidia arguta genotypes using whole-genome re-sequencing and links them to functional genes involved in stress responses and hormone signaling.

This paper develops a multi-scale modeling approach to study amyloid fibril growth kinetics and mutation effects using Markov State Models derived from molecular dynamics simulations.

This study shows that loss of SHMT2 promotes 5-FU resistance in CRC by inducing autophagy through p53 regulation.

This study shows APOC2 promotes colorectal cancer by altering lipid metabolism and activating PHF8 transcription, linking it to poor prognosis.

The paper shows that aerosolized TLR agonists reduce Sendai virus lung burden and chronic asthma-like disease in mice by suppressing inflammation and IL-33 production.

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

This study identifies multiple PCNA-interaction motifs in ESCO2 essential for sister chromatid cohesion during DNA replication.

This paper develops a CFD-DEM model to simulate bacterial twitching motility in shear flows and identifies optimal wall shear stress for efficient upstream movement.

The paper identifies Ms4a3 as a marker for tracking monocyte-derived cells and quantifies their contribution to tissue-resident macrophages during homeostasis and inflammation.

NUFEB simulates microbial community dynamics using individual-based modeling, supporting large-scale simulations and detailed biological, chemical, and physical processes.

This paper introduces faster deconvolution and multiview fusion methods, achieving speedups of 10 to several thousand-fold over previous approaches.

The paper identifies epigenetic drivers of esophageal squamous cell carcinoma through multi-omics analysis, revealing hypomethylation patterns and non-canonical WNT signaling activation.

This study evaluates the efficacy and adverse effects of antibiotics in treating M. abscessus pulmonary disease, finding that four antibiotics correlate with treatment success but are associated with severe side effects.

This study examines gut microbiome differences between lung cancer patients and healthy individuals, finding altered microbial composition but unclear links to cancer development.

This paper identifies and characterizes an NAD-dependent xylitol dehydrogenase from Gluconobacter oxydans WSH-003, showing high activity for D-sorbitol to D-fructose conversion and distinct optimal conditions.

This paper introduces a dual value system (DVS) to assess ecosystem services, demonstrating its application in valuing water provision in the Zhujiang River Basin and showing it overcomes limitations of traditional methods.

This study identifies glucose starvation and SGLT2 inhibition as synthetic lethal strategies for EGFR-WT/LKB1-mutant NSCLC, showing efficacy in xenograft models.

This paper introduces a microfluidic chip that improves single-cell encapsulation efficiency by fourfold, achieving a 3% co-capturing rate with low doublet rates in sequencing data.

This study identifies TMC1 as providing a background leak conductance in mouse auditory hair cells, essential for action potential firing and tonotopic organization.

This study characterizes the colonization dynamics of Rhodopseudomonas palustris GJ-22 on tobacco phyllosphere and shows it induces plant resistance to Tobacco mosaic virus.

This paper introduces a new indicator, optional capacity value (OCV), to quantify payments for ecosystem services (PES) in the Zhujiang River Basin by considering the benefits of basic ecosystem services.

This study shows that climate change has caused a northward shift in the range of wheat pests, leading to increased crop damage despite pesticide use.

This study generates triple knockout mice lacking Fut1, Fut2, and Sec1 to deplete H antigen, finding normal development and fertility despite the absence of the antigen.

This paper introduces a sparse infomax algorithm using Hoyer projection for improved pattern recovery in simulated structural MRI and SNP data, showing better sparseness and performance under low signal-to-noise ratio conditions.

This study identifies genes regulating cell death in Staphylococcus aureus through a genome-wide screen, revealing both death-resistant and death-sensitive mutants with implications for virulence and antibiotic persistence.

This study shows radiation-resistant prostate cancer cells enhance survival and resistance of sensitive cells in spheroids through competitive and antagonistic interactions.

This study investigates the selectivity of 4-aminoquinolines for the alpha2A-adrenoceptor using docking, molecular dynamics, and mutagenesis to identify binding sites and affinity determinants.