J. Chen

This study uses multi-omics analysis to examine the effects of simulated weightlessness on rhesus macaques, identifying molecular changes in blood, muscle, brain regions, and fecal samples.

The paper shows that tetraploid cells lose extra centrosomes through natural selection, favoring cells with a single centrosome in asymmetric divisions.

The paper uses genomic data to infer the demographic history of Norway spruce and quantify recent material transfers in a Swedish breeding program.

This study identifies EphA4 as a new Kaposi’s sarcoma-associated herpesvirus entry receptor, showing it promotes viral fusion and infection better than EphA2 in HEK293T cells.

The paper detects Leishmania spp. in snakes from Northwest China and identifies three species using phylogenetic analysis.

The paper analyzes the genetic basis of local adaptation in Norway spruce using mixed-origin trees and phenotypic data to assess the potential of assisted gene flow for climate change adaptation.

This study shows miR-425 suppresses EMT and TNBC development by targeting TGF-β1/SMAD3 signaling pathway through experiments in cell lines and xenograft models.

The paper identifies distinct microbial, metabolic, and ecological differences between deficient and proficient mismatch repair colorectal cancers using microbiome and metabolomic analyses.

This study shows that CHAPSO detergent reduces orientation bias in bacterial transcription complexes by preventing particle adsorption at the air/water interface during cryo-EM.

This paper identifies and characterizes a novel paraoxonase-like enzyme in Trichoderma atroviride strain T23 that degrades DDVP and related organophosphate-oxons, showing high activity and specific kinetic parameters.

The paper uses high-resolution imaging to reveal the structure and function of the SUN-KASH complex in yeast centrosome insertion, identifying Mps3 as a fifth SPIN component and a novel LINC complex.

This study identifies PP2AB55δ as a mediator of high fermentation rates in sake yeast strains through the TORC1-Greatwall-PP2AB55δ pathway.

This study shows that osteoclast precursor cells migrate toward low fluid shear stress regions, regulated by calcium signaling, under gradient fluid shear stress.

This study shows that hydrogen sulfide promotes nodulation and nitrogen fixation in soybean-rhizobia symbiosis by upregulating key genes and proteins involved in symbiosis and nitrogen metabolism.

This study finds microbial dysbiosis is not significantly linked to obesity in predicting obesity-associated CRC risk, using meta-analysis of 16S rRNA and WGS data.

This study identifies interface residues that drive allosteric transitions and control tetramer assembly in L-lactate dehydrogenase using computational simulations and structural perturbation methods.

The paper develops a model for studying small cell lung cancers by generating pulmonary neuro-endocrine cells and tumors from human embryonic stem cells through genetic manipulation.

This study develops a fluorescent probe to measure glutathione concentrations in the nucleus and cytosol, finding no significant concentration gradient between them.

The paper presents the first crystal structures of SERCA2a, revealing structural and regulatory differences from SERCA1a and providing insights into its function in cardiac muscle.

This study identifies BmNPC1 as a critical host receptor for baculovirus infection, showing its interaction with the viral glycoprotein gp64 and role in endosomal fusion.

The paper shows that Drosophila midgut epithelia polarize without canonical polarity factors, using integrin adhesion instead, suggesting conserved diversity in polarity mechanisms across species.

This study identifies an independent promoter for SloR in S. mutans, showing SloR autoregulates via transcriptional activation of its own promoter and repression of the sloABC operon.

This study identifies mutations in specific genes associated with clofazimine resistance in Mycobacterium abscessus through whole genome sequencing of resistant mutants.

The paper identifies novel mutations in several genes associated with pyrazinoic acid/pyrazinamide resistance in Mycobacterium tuberculosis.

The paper identifies a novel NF-κB nucleolar stress response pathway triggered by PolI complex disruption, showing TIF-IA degradation and therapeutic relevance in colorectal tumors.

This study determines the structure of M. tuberculosis RNA polymerase with fidaxomicin, revealing how it inhibits transcription by blocking essential motions.

The paper presents two cryo-EM structures of the human KATP channel complexed with ATP and ADP, revealing their roles in channel regulation.

This paper introduces a method combining instant structured illumination microscopy with TIRF to achieve higher resolution and faster imaging of live samples near the coverslip.

This study identifies USP11 as a deubiquitylase that stabilizes p21, affecting cell cycle progression and DNA damage responses.