J. Han

This study shows Talaromyces marneffei induces M2 macrophage polarization by downregulating SOCS3 and activating TLR9, enhancing fungal survival.

This study produces SARS-CoV-2 virus-like particles in insect cells for vaccine development and research.

This paper identifies Rab11a's role in facilitating cell-cell spread of influenza A virus genomes via tunneling nanotubes, enabling genome reassortment and bypassing extracellular barriers.

This paper develops a microengineered lung organ chip model to study SARS-CoV-2-induced lung injury and immune responses, revealing distinct cellular responses and the role of immune cells in inflammation.

This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.

This study tracks SARS-CoV-2 specific B- and T-cell responses in convalescent patients 6-8 months post-infection, finding sustained memory cell responses despite declining antibody levels.

The paper identifies a high-affinity human monoclonal antibody against Pfs230 that blocks oocyst formation in mosquitoes by targeting gamete surfaces.

This study identifies T-bet deficiency as a cause of mycobacterial disease by impairing IFN-γ production in innate and innate-like adaptive lymphocytes.

This study shows that aphid performance on soybean plants depends on feeding location, with stems providing better nutrient quality and accessibility, leading to higher populations and faster development.

This study uses EMPEM to track human antibody responses to H5N1 vaccination, showing persistent stem-binding antibodies and transient head-binding antibodies after immunization.

The paper shows that methylmalonic acid accumulation with age promotes tumor progression by inducing SOX4 and reprogramming cancer cells.

The paper shows that the p150 isoform of ADAR1 prevents sustained RIG-I signaling and apoptosis during influenza virus infection, independent of RNA editing.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

This study examines the effects of rhein on bile acid homeostasis in rats, showing dose-dependent changes in bile acid levels and transporter expression without liver or kidney toxicity.

This paper introduces a novel tissue biopsy culture method that improves fungal detection compared to traditional methods.

This study identifies eight distinct evolutionary lineages in the common pheasant, revealing regionally divergent drivers of diversification and suggesting the species should be split into three species.

This study identifies RpvA, a LysR-type regulator in S. aureus, which controls persister formation and virulence by modulating metabolism and virulence gene expression.

The paper shows that 3D matrix stiffness and dimensionality influence the expansion of hematopoietic stem and progenitor cells in vitro, affecting lineage fractions and gene expression.

This study identifies circadian PER2 amplitude enhancement in endothelial cells as a novel cardioprotective strategy that mimics HIF1A metabolic adaptation during myocardial ischemia.

This study uses bibliometric analysis to examine soil remediation research trends from 1988-2018, identifying key topics and institutional contributions.

This paper develops an LCMS-based assay to detect DOACs in trauma patients, achieving high accuracy and identifying potential medication reconciliation issues.

KnowEnG is a cloud-based platform that provides tools for analyzing genomics data using knowledge-guided data-mining and machine learning, demonstrating its utility in cancer research.

This paper examines how varying proportions of soft rock and sand affect soil organic carbon mineralization and particle composition, finding that ratios of 1:5 to 1:2 enhance organic carbon accumulation and stability.

This study characterizes and repurposes the endogenous Type I-F CRISPR-Cas system of Zymomonas mobilis to create an efficient genome engineering toolkit with 100% efficiency in various genetic modifications.

This paper introduces a point-of-care NMR system to assess oxidative stress in diabetes patients, enabling rapid sub-stratification based on redox status and glycemic levels.

The paper shows microtubules regulate tau condensation, which spatially controls microtubule severing enzymes and motor movement.

The paper develops IPTG-controlled conditional suicide plasmids for efficient and regulatable transposon mutagenesis in multiple bacterial species.

This study identifies Cyclin B3's specific role in facilitating metaphase-to-anaphase transition in mouse oocyte meiosis I, while showing it is not required for oocyte maturation or sister chromosome segregation.

This study shows Bclaf1 is degraded by alphaherpesvirus US3 and is critical for type I interferon signaling and antiviral immunity.