J. Han

ePlatypus provides a computational ecosystem for immunogenomics data analysis, integrating diverse modalities and tools to study adaptive immunity and computational immunology.

This study identifies antibodies effective against Omicron by analyzing epitope changes and binding patterns, showing their ability to neutralize the virus through a conserved mechanism.

This study characterizes Lactococcus garvieae isolates from bovine mastitis in China, identifying genetic diversity, antimicrobial resistance, virulence factors, and potential host adaptation.

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.

This study shows dehydration and infection increase feeding in western flower thrips, likely due to glycogen depletion, affecting their survivorship and disease spread.

The paper shows human and avian influenza viruses use different glycoconjugate types for infection, with avian strains using a broader range.

This study develops a live-cell method to detect senescence in mesenchymal stem cells using micro magnetic resonance relaxometry, showing strong correlation with senescent markers.

This study shows DNA viruses like TYLCV undergo intracellular population bottlenecks, limiting replication to no more than three genome copies per cell, ensuring lethal mutations are purged.

This study develops a regenerative immunotherapy using helminth-derived soluble egg antigen to promote tissue repair in multiple injury models.

This study identifies stage-specific microbial and metabolic changes in RA progression using multi-omics data from a cohort of patients.

This study characterizes the HERV-K (HML-8) group in the human genome, identifying 40 proviruses and 5 solo LTR elements and determining their integration time and genomic distribution.

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

This study identifies OXI1 and AGC2-2 as kinases that phosphorylate PDR6, enhancing camalexin efflux and disease resistance in plants.

The paper traces the evolutionary emergence of metabolic signaling via nucleoredoxin-like genes, showing their role in photoreceptor communication and glucose regulation across species.

This study shows that bacterial amino acid biosynthesis prevents rhizosphere alkalization and immune activation in Arabidopsis by reducing glutamate precursors.

The paper measures in vivo electric fields during multi-electrode transcranial electrical stimulation and validates linear superposition and quasi-static assumptions.

The paper identifies a novel S2 epitope recognized by a public antibody class in SARS-CoV-2-reactive B cells, which becomes exposed on vaccine-optimized spike proteins.

The paper investigates the effects of morpholino-mediated MR knockdown on glucocorticoid signaling and neuroplasticity in wild ocellated wrasse, finding brain region-specific impacts on behavior and fitness traits.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

The paper describes exceptionally preserved muscle systems in Cambrian cnidarians, providing insights into the evolution of muscle systems in early animals.

This study identifies pre-existing human B cell responses to computationally optimized H1 hemagglutinin vaccines, showing cross-reactivity and functional antibodies targeting head, central stalk, and anchor epitopes.

This study shows SARS-CoV-2 indirectly causes BBB injury and neuroinflammation through systemic inflammation, not direct viral infection, using a linked alveolus-BBB organ chip platform.

The paper identifies TOP1 inhibitors as therapeutic agents for neuroinflammation and develops a DNA origami nanosystem for targeted delivery to myeloid cells.

This study shows that age-related senescent T cells promote type 3 immunity, which inhibits tissue repair, and that blocking this pathway improves healing in older animals.

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

Echidna simulates single-cell immune receptor repertoires and transcriptomes, enabling benchmarking of clonotyping and phylogenetic analysis tools.

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

This study identifies Rab11a as a critical host factor for influenza A virus genome assembly by facilitating vRNP congregation and specific interactions.

This study shows that cholecystokinin reduces β-cell apoptosis in human islets both in vitro and in a transplant model, suggesting its therapeutic potential for diabetes.