J. Huang

This paper identifies FvLcp1, a secreted type-D fungal LysM protein with chitin-binding domains, as a key factor in fumonisin production and host recognition in F. verticillioides during maize infection.

The paper investigates the association between serological responses to HHV-6A and HHV-6B and multiple sclerosis risk, finding increased risk with HHV-6A antibodies and interaction with EBV.

This study shows that 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic mice by scavenging reactive dicarbonyls and improving HDL function.

This study identifies imidazolopiperazines as targeting the Plasmodium falciparum secretory pathway by inhibiting protein trafficking and ER expansion.

This paper develops a CRISPR-Cas9-based pipeline to generate pancreatic cancer mouse models with complex genotypes using AAV-delivered sgRNAs in adult mice.

This study shows that SS-31 reverses mitochondrial fragmentation and increases ROS in DCMA fibroblasts, suggesting it as a potential therapy for this mitochondrial cardiomyopathy.

This paper develops rice tissue media to enhance conidiation of Ustilaginoidea virens, improving pathogenicity testing and genetic analysis for false smut resistance.

This study shows that FvSec4 is essential for hyphal development, virulence, fumonisin B1 production, and stress response in Fusarium verticillioides.

This study uses single-cell RNA sequencing to analyze cellular heterogeneity in mouse pancreatic ductal adenocarcinoma progression, identifying epithelial-to-mesenchymal transition, inflammatory macrophages, and fibroblast subtypes.

This study shows that reactive dicarbonyl scavengers reduce MPO-mediated HDL oxidation, preserve HDL function, and improve cholesterol efflux in FH-HDL and mice.

This study identifies YAP/TAZ as regulators of single-cell volume, showing their role extends beyond cell cycle duration and shape, and they influence division volume independently of mTOR.

This paper introduces a high-throughput method for drug screening using tumor organoids and identifies effective drugs for ovarian cancer within a week of surgery.

This study examines how intra- and intermolecular triplet-state quenching affects photobleaching and photoswitching in fluorophores, showing competition between these processes and identifying new roles for intramolecular quenchers.

This study uses single-cell RNA sequencing to analyze transcriptomic changes in pancreatic cancer precursors, revealing epithelial and microenvironmental heterogeneity during progression to cancer.

This study identifies reduced diffusional conductance to CO2 as the main factor limiting photosynthesis in salt-stressed rice leaves.

The paper identifies and validates single-copy gene markers for phylogenomic studies in ray-finned fishes using comparative genomics and empirical testing across 83 species.

This study identifies 208 imprinted genes in rice, showing limited transposable element association, intraspecific variation, and conservation of imprinting at some loci across plant species.

This study identifies a Calcineurin-FoxO-MuRF1 signaling pathway that mediates Ca2+ overload-induced myofibril degradation in cardiomyocytes using zebrafish models.

This study shows PD-1 inhibits T cell activation by preferentially dephosphorylating CD28 over TCR, revealing CD28 as a primary target for PD-1-mediated suppression.