J. Wang

The paper presents a platform using C. elegans to track extracellular vesicles and identify their cargo, demonstrating animal-to-animal EV targeting during mating.

This study shows that m6A modifications regulate intestinal immunity and rotavirus infection by modulating IRF7 and IFN expression through METTL3 in intestinal epithelial cells.

This study identifies previously unknown translated ORFs in Mycobacterium tuberculosis using ribosome profiling, revealing pervasive translation of short ORFs that may contribute to evolutionary innovation.

The paper investigates how vegetation structure influences soil cyanobacterial communities across soil development in global biomes, finding stable communities in most cases but shifts during vegetation transitions.

This study identifies a viral miRNA-like small RNA, vmiR-5p, from SARS-CoV-2 that represses host genes through the RNA interference pathway.

This study identifies SNP markers associated with salt tolerance traits in upland cotton through genome-wide association analysis.

The paper examines how repeated micropollutant exposure affects microbial community succession and degradation patterns in freshwater systems.

NeuralDock rapidly predicts protein-small molecule binding energy and affinity without prior ligand knowledge, validated against physical docking methods.

This paper develops a fluorogenic EXO-Probe Aptamer system to visualize and track exosomal RNAs, enabling imaging, quantification, and colocalization with cellular markers.

The paper develops a framework to quantify DOM-microbe associations under global change, finding that molecular traits and nutrient enrichment influence these interactions differently in subarctic and subtropical climates.

This study identifies 97 chemical constituents of Jing-Fu-Kang granules and reveals 531 common targets and 136 pathways involved in its mechanism for cervical spondylosis using mass spectrometry and network pharmacology.

This study identifies early megakaryocyte lineage-committed progenitors in adult mouse bone marrow and proposes a differentiation model involving intermediate progenitors.

The paper identifies two circRNAs whose m6A methylation synergistically promotes pulmonary fibrosis by targeting eIF4A3, mediated by METTL3.

This study investigates the mechanism of tripeptide trimming by γ-secretase using biochemical experiments and simulations, revealing structural changes required for the process and how mutations affect it.

This study regenerates functional B lymphopoiesis from pluripotent stem cells (PSCs) using Runx1, Hoxa9, and Lhx2, producing antigen-specific antibodies and immune memory in B-cell deficient animals.

This study identifies RTN3 as a proresolving mediator that suppresses antiviral responses by inhibiting TRIM25-mediated K63-linked polyubiquitination of RIG-I, reducing neutrophil infiltration and inflammation.

This study shows GM1 promotes Aβ oligomer formation and maintains their stability on membranes, supporting the Aβ ion channel hypothesis and highlighting GM1 as a target for Alzheimer's disease research.

This study identifies novel SARS-CoV-2 epitopes using mass spectrometry and validates their immunogenicity by T cell recognition.

This study identifies transcription factors, protein kinase, and aspartic peptidase that synergistically regulate salicylic acid-induced reduction in ethylene biosynthesis in kiwifruit.

The paper develops a cross-tissue single-nucleus RNA-seq atlas to identify cell types and gene functions in health and disease.

This study investigates how plasma-activated water (PAW) affects the viability and cellular responses of Fusarium graminearum, finding significant inhibition of microbial activity and damage to cell wall, membrane, and mitochondria.

This study shows that in silico predicted SARS-CoV-2 epitopes do not reliably elicit T cell responses against naturally presented epitopes.

This study uses dual-lipid metabolomics to compare lipid compositions of MTB and MB and their effects on bovine alveolar macrophages, revealing distinct metabolic responses and colonization mechanisms.

This study examines how the COVID-19 pandemic affected aversive episodic memory through free recall, recognition, and episode order tasks, finding impairments in aversive memory and no emotional benefit in order tasks.

This study analyzes the gut microbiomes of two stingless bee species, finding that bacterial richness in T. carbonaria correlates with host wing size and geography.

This study compares clonal evolution across right-sided colon cancer, left-sided colon cancer, and rectal cancer patients, finding differences in evolutionary patterns and identifying polyclonal origins of lymph node and extranodal tumor deposits.

This paper develops a machine learning tool called STEP3 to accurately define bacteriophage virion components using evolutionary features, validated with mass spectrometry.

This study shows that combined thermal and mechanical stimuli synergistically enhance chondrogenesis through calcium signaling via TRPV4 channels.

This paper develops a real-time single-molecule RNA sequencing method to visualize telomerase catalysis and structural dynamics at single-nucleotide resolution.