J. Wang

This study measures Neu5Gc serum biomarker levels in breast cancer patients and finds elevated levels at all disease stages, with high sensitivity and specificity for detection.

This study identifies potent SARS-CoV-2 PLpro inhibitors through high-throughput screening and a FlipGFP-based assay, showing improved antiviral activity compared to existing compounds.

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

The paper presents the cryo-EM structure of TMEM120A, revealing it binds coenzyme A and shares structural features with ELOVL fatty acid elongase, suggesting a potential role in fatty acid metabolism rather than mechanosensation.

This study identifies a lysosomal lipid signaling pathway from fat to neurons in C. elegans that promotes longevity by regulating neuropeptide signaling.

This study uses multi-color super-resolution imaging to analyze the spatial organization of coronavirus RNA during infection and assess antiviral drug effects.

The paper identifies MK-derived immune-stimulating cells (MDICs) that enhance host defense against bacterial infections by interacting with myeloid cells and producing cytokines.

This study shows FXa cleaves SARS-CoV-2 spike protein, blocking viral entry, but B.1.1.7 variant is resistant, and FXa inhibitors like rivaroxaban reduce this protection.

The paper introduces a single-cell cyclic multiplex in situ tagging (CycMIST) technology to comprehensively profile functional proteins in single neurons, demonstrating its ability to detect 182 proteins in a neuron cell line and reveal differential expression in an Alzheimer's disease model.

The paper quantifies how two alternative promoters of the Bicoid target gene hunchback are differentially regulated by Bcd through enhancer-promoter interactions in Drosophila embryos.

The paper identifies five loci associated with maturation timing in wild Atlantic salmon using haplotype and multi-SNP Bayesian methods, showing simple genetic architecture.

The paper investigates fungal-microalgal interactions in a marine environment using metabolomics, revealing toxin production changes and bacterial influence on microalgal resilience.

The paper reports structures of bradykinin receptors bound to their ligands and reveals mechanisms of selectivity and activation, providing insights for drug design.

This study examines how nitrification inhibitors and straw incorporation affect N2O emissions and microbial communities in different cropland soils, finding that their effects vary by soil type.

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

This study shows that IL-6 promotes PSAT1 expression and serine metabolism in TSC2-deficient cells, linking IL-6 to mTORC1 hyperactivity and potential therapeutic targets.

This study uses molecular dynamics simulations to analyze chromosome structural dynamics during cell fate transitions, revealing merging pathways and distinct cancer progression routes.

This study shows that influenza A M2 forms various oligomers influenced by chemical environment, challenging the previous monodisperse tetramer model.

This paper introduces a new histologic grading system for murine knee osteoarthritis that scores the entire joint, showing high reproducibility and sensitivity for detecting OA progression.

The paper investigates the ecological and genetic factors maintaining color polymorphism in grasshoppers, finding that predation and genome structure influence morph frequencies and crypsis.

The paper identifies the TPLATE complex as a mediator of membrane bending in plant clathrin-mediated endocytosis, which occurs independently of actin and against high turgor pressure.

The paper identifies antiviral drugs by analyzing RNA-host protein interactomes of SARS-CoV-2, EBOV, and ZIKV.

This study shows that cuticular hydrocarbons in Anopheles coluzzii males are linked to mating success and insecticide resistance.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This study compares gut microbiota composition between officials in a stable environment and train drivers in a dynamic environment, finding differences in diversity and functional predictions.

This study shows that hydroxychloroquine increases anxiety and depressive behaviors and alters gene expression in mouse brains, suggesting potential mental health risks.

This study investigates the role of PQN-59 and GTBP-1 in stress granule formation and development in C. elegans, finding that PQN-59 contributes to development beyond stress granule assembly.

This paper introduces a reduced graphene oxide membrane as a supporting film for cryo-EM, improving resolution and particle absorption for sub-100 kDa biomolecules.

The paper identifies a dimmer-switch gene regulation mechanism in yeast by decoupling transcription factor expression and activity.