J. Wang

This paper introduces two deep learning methods for designing proteins with specific functional sites, showing they can generate diverse proteins with desired properties.

This study identifies RPRM as a negative regulator of ATM levels through phosphorylation by CDK4/6, enhancing cellular sensitivity to genotoxic agents and radiation.

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

This paper identifies two extrathymic Aire-expressing cell types with transcriptional and genomic similarities to thymic epithelium and shows their role in immune tolerance.

The paper validates or invalidates reported SARS-CoV-2 PLpro inhibitors using enzymatic, thermal shift, and cell-based assays, finding most compounds lack binding or cellular inhibition.

The paper uses AlphaFold models to predict protein structures for understudied human proteins, finding that 95% of models with confidence scores above 80 are accurate at the fold level.

This study shows brilacidin has broad-spectrum antiviral activity against multiple human coronaviruses by targeting both the virus and host cell heparan sulfate proteoglycans.

This paper reports a novel, highly divergent Canine Distemper Virus lineage causing distemper in ferrets in Australia, with less than 93% similarity to other lineages and vaccine strains.

This study compares alpha-synuclein fibril structures from preclinical and postmortem Parkinson's disease patients, showing structural and pathological differences in fibril conformation during disease progression.

The paper identifies IgA-secreting AT2-like cells in fibrotic lungs and shows their role in ECM IgA deposition through spatial transcriptomics and scRNA-seq.

This study identifies protective and aggressive bacterial subsets and metabolites in PSC patients and mice, showing their impact on hepatobiliary inflammation and fibrosis.

This study presents the structure of the yeast nuclear pore complex using cryo-EM, revealing its functional adaptations and evolutionary links.

The paper develops a yeast-based screening tool to identify PfATP6 inhibitors, confirming artemisinins target PfATP6 and discovering new inhibitor classes.

The paper examines sex ratio polymorphism across 23 Caenorhabditis nematode species, finding that 12 species show strain-level variation, and challenges the sperm competition model as the sole explanation for biased sex ratios.

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

BipotentR identifies immune-metabolic regulators for bipotent anticancer drugs, demonstrating ESRRA inhibition's effects on tumor metabolism and immune mechanisms.

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.

This study develops a human hepatic organoid model of ARPKD liver fibrosis, showing that the ARPKD mutation leads to fibrosis through TGFβ and PDGFRB pathways.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This study introduces scStereo-seq, a method for single-cell spatial transcriptome profiling in Arabidopsis leaves, revealing cell type-specific spatial gene expression gradients and developmental trajectories.

This study examines how the dual deletion of glnR and mtrA affects nitrogen metabolism gene expression in Streptomyces venezuelae, revealing GlnR's decisive role and MtrA's GlnR-dependent regulation.

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.

This paper introduces a deep learning method for single-frame super-resolution microscopy, enabling live-cell imaging at nanometer-scale spatial and millisecond temporal resolutions.

This study uses a semi-synthesis approach to generate N-terminal acetylated HMGB1 proteins and shows that this modification affects its interaction with heparin and stability.

This study engineers natural killer cells to block the CD73-adenosine axis in solid tumors, leading to tumor cell killing and enhanced NK cell activity.

The paper develops FAST, an improved gene-interfered ferroptosis therapy that shows enhanced antitumor activity and tumor eradication compared to its predecessor GIFT.

The paper identifies TOP1 inhibitors as therapeutic agents for neuroinflammation and develops a DNA origami nanosystem for targeted delivery to myeloid cells.

This paper designs novel membrane receptors with enhanced activity and stability through engineered allosteric networks involving solvent-mediated interactions.

This paper introduces PPI-GaMD, a computational method that efficiently calculates binding thermodynamics and kinetics of protein-protein interactions using all-atom simulations.