J. Wang

This study identifies TGF-beta and TSP1 as key drivers of microtube formation in glioblastoma, showing their role in invasion and treatment resistance.

This study shows that IDO1 promotes PD-1 expression on CD8+ T cells in ovarian tumors through kynurenine-mediated AHR activation, suggesting therapeutic targeting of these pathways.

The paper examines the serological response to the N-terminal domain (NTD) of SARS-CoV-2, showing it is less cross-reactive with SARS-CoV and less effective as an immunogen compared to the RBD.

This paper develops a robotic system and model-based approach to estimate viscous damping and stiffness in Parkinsonism, showing that these metrics decrease with deep brain stimulation and better differentiate rigidity changes than existing clinical scores.

The paper identifies transposable elements (TEs) as genetic drivers of stemness in normal and leukemic hematopoiesis, showing their role in maintaining stem cell properties through chromatin accessibility.

This study shows that gut microbiota in Anopheles stephensi affects tryptophan metabolism, with Pseudomonas alcaligenes reducing 3-HK to protect against Plasmodium infection.

The paper validates that single-domain antibodies bind RBD of SARS-CoV-2 from original, UK, and South African variants, ensuring their effectiveness in antigen detection tests.

The paper develops a 2-step formate-reduction pathway by screening and engineering enzymes, but finds no in vivo biomass assimilation despite in vitro activity.

The paper uses a landscape-switching model to study chromosomal structural changes during cancerization and reversion, finding non-monotonic structural transitions and structural similarities to embryonic stem cells.

The paper introduces thiophosphopeptides that target the Golgi apparatus and selectively kill cancer cells through enzymatic self-assembly.

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

The paper identifies a nadA mutation causing nicotinic acid auxotrophy in the AIEC strain NC101, enabling growth in minimal media and enhancing in vitro functional studies.

This paper develops an integrated mass spectrometry strategy to analyze the complex glycosylation of erythropoietin, identifying N- and O-glycan structures and their site-specific modifications.

This study identifies ciliary tip and base as distinct sites for EV shedding in C. elegans and shows ciliary trafficking machinery regulates EV biogenesis and signaling.

This study shows albendazole reduces endoplasmic reticulum stress in mice infected with Echinococcus multilocularis by modulating UPR-related proteins and miRNAs.

This study shows Kv1.3 is highly expressed in human PDAC and novel Kv1.3 inhibitors combined with chemotherapy significantly reduce tumor growth in mouse models.

This study identifies and characterizes six AcMNPV-encoded miRNAs, showing they regulate both viral and host genes through suppression or enhancement of target expression.

This study shows ESD1 regulates seed setting rate in rice by controlling embryo sac development, as loss-of-function mutants exhibit reduced seed setting rates and abnormal embryo sac differentiation.

This study produces SARS-CoV-2 virus-like particles in insect cells for vaccine development and research.

This paper presents a computationally designed dual-ring biobot that demonstrates robust forward motion and rotational steering through differential electrical stimulation.

The paper identifies a reservoir of stem-like CD8 T cells in tumor-draining lymph nodes that sustain anti-tumor immunity by maintaining TCF1 expression and resisting terminal differentiation.

This study evaluates GC-376's in vivo antiviral efficacy against SARS-CoV-2 in K18-hACE2 mice, showing reduced viral loads and inflammation but no improvement in clinical symptoms or survival.

The paper develops tTARGIT AAVs to precisely manipulate intersectional neuronal populations by combining Flp and Cre recombinases, demonstrating their use in targeting LepRbVMH neurons.

This study examines fungal co-occurrence networks along an elevation gradient on Mt. Norikura, finding that climate factors dominate network connectivity patterns, with significant declines between 700 m and 1500 m elevation.

This study identifies BRD2 as a regulator of ACE2 transcription and shows that BRD2 inhibitors block SARS-CoV-2 infection in human cells and animal models.

This study examines how meteorological factors affect wheat irrigation water requirements in the Beijing-Tianjin-Hebei region from 2000 to 2019, showing trends and correlations with climate variables.

This study identifies the DAXX-SREBP axis as a driver of lipogenesis and tumorigenesis by showing its role in activating lipogenic gene expression and promoting tumor growth.

This study investigates the neuroprotective role of CTRP1 in TBI rats, finding it reduces inflammation and modulates autophagy through mTOR activation.

The paper identifies proinflammatory gut microbiome features in SLE patients through metagenomic analysis and shows potential autoimmunogenic mechanisms.

This study compares the molecular mechanisms of pluripotent reprogramming and malignant transformation, revealing shared and distinct features of cellular plasticity and identifying bHLH transcription factors as key regulators.