J. Wang

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

This study identifies HspB8's role in preventing FUS condensate hardening by interacting with its RNA-binding domain, suggesting a mechanism to prevent neurodegenerative disease-associated phase transitions.

The paper identifies PD-L1-lncRNA, a long non-coding RNA splice variant of PD-L1, that promotes lung adenocarcinoma progression by enhancing c-Myc activity.

This study examines soil bacterial and fungal community patterns and co-occurrence networks along depth and altitude gradients in cold-temperate forests, finding altitude has a stronger impact than depth.

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

The paper examines how prior H5 exposure influences IgG responses to H5 vaccination, finding that antibody breadth and strength correlate with antigenic distance to priming strains.

This study identifies novel SARS-CoV-2 receptors through a CRISPR activation screen, revealing LDLRAD3, TMEM30A, and CLEC4G as functional receptors independent of ACE2.

This paper presents a large repertoire of high-affinity nanobodies against SARS-CoV-2 Spike protein with potent neutralization properties and resistance to viral variants.

The paper examines how non-structural carbohydrates (NSCs) and fine root traits vary across root branch orders in Fraxinus mandshurica seedlings under different drought and soil conditions.

This study examines how simulated microgravity affects biofilm formation in Proteus mirabilis and identifies gene expression changes linked to reduced biofilm formation.

The paper identifies SWEET5 as a hexose transporter mediating galactose sensitivity in Arabidopsis pollen germination through the action of galactokinase GALK.

The paper uses single-molecule fluorescence assays to study eukaryotic translation termination dynamics in yeast, revealing a conserved multi-step process involving eRF1 and eRF3.

This study identifies racial differences in androgen metabolism and receptor signaling in prostate cancer, showing African American men use an alternative pathway for DHT biosynthesis associated with disease progression.

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

This study shows that knocking down PxRdl2 with dsRNA enhances the insecticidal effects of GABAR-targeting compounds against Plutella xylostella.

This study shows phosphopeptide nanofibers enable caveolae-mediated endocytosis and endosomal escape via TNAP clustering in lipid rafts.

This study identifies the structural and biochemical mechanism by which DPP9 inhibits NLRP1, preventing its activation and maintaining it in an auto-inhibited state.

The paper identifies a novel SARS-CoV-2-related bat virus, PrC31, with complex recombination events and partial genetic similarity to SARS-CoV-2.

This study shows that small spherical AuNPs can deliver siRNA efficiently to plant leaves without entering cells, challenging the need for nanoparticle internalization in RNA delivery.

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

This study reports the crystal structures and biochemical characterization of SOQ1 lumenal domains, revealing their structural organization and potential regulatory mechanisms in suppressing qH.

This study shows that matrix stiffness affects intestinal stem cell fate by reducing Lgr5high ISCs and promoting differentiation into goblet cells, mediated by YAP nuclear translocation.

This study identifies RasGRP1 as a bifunctional regulator that promotes acute inflammation and inhibits inflammation-associated cancer growth.

This study shows that high oxygen tension upregulates integrin α6 in nucleus pulposus cells, which protects against intervertebral disc degeneration by reducing apoptosis and oxidative stress.

This study shows SUMOylation of GMFB increases its stability and trans-localization, upregulating inflammatory pathways in RPE cells under oxidative stress and inflammation.

The fungal pathogen Ustilaginoidea virens disarms chitin-triggered immunity in rice flower via a secreted chitinase, revealing a mechanism of disease susceptibility.

This study shows that gut microbiota influence dopamine levels, which in turn affect social interaction and color preference in zebrafish larvae.

The paper shows that YKL-05-099, which inhibits SIKs and CSF1R, increases bone formation without increasing bone resorption in mice.

The paper investigates syncytia formation between SARS-CoV-2 infected and ACE2-expressing cells, finding that it leads to pyroptosis via Caspase-9 and GSDME activation, contributing to severe COVID-19 inflammation.

This study uses single-cell RNA sequencing to identify cell type-specific molecular changes and altered intercellular communications in COPD, linking them to alveolar epithelial dysfunction.