J. Xu

This study shows that p53 deficiency in tumors enhances immunogenicity by increasing IL-33, which improves response to PD-1 ICB therapy in a mouse model.

The study investigates how ICOS/ICOSL signaling regulates macrophage polarization and IL-33's role in liver fibrosis progression in mice with schistosomiasis.

This study uses RNA-seq to identify molecular changes in kidney cancer among people living with HIV, finding altered expression of specific genes and pathways associated with cancer progression.

This study shows macrophages can migrate across non-adhesive PEG surfaces by adopting a mesenchymal mode, overcoming the limitations seen in other cell types.

This study develops an Omicron-specific mRNA vaccine that shows superior neutralizing antibody responses in mice, hamsters, and macaques compared to existing vaccines.

This study identifies how coronaviruses like PEDV and SARS-CoV-2 evade antiviral responses by manipulating caspase-1 and inhibiting IFN-I signaling through proteolytic activities.

This study identifies Galectin-8 as a functional ligand of LILRB4 that promotes MDSC expansion and tumor growth, suggesting its blockade as a potential immunotherapy strategy.

This paper introduces a method to image endogenous mRNAs in live animals with high temporal resolution and applies it to study gene expression dynamics in C. elegans epidermis.

This study shows that osteocyte ablation in mice leads to senescence-associated changes in bone and bone marrow lineages, causing sarcopenia, osteoporosis, and shortened lifespan.

This study identifies differential proteins and pathways affected by BF-TK/GCV treatment in gastric cancer cells, showing its anti-metastatic effects through proteomics and functional assays.

This study investigates rhubarb's effects on constipation-induced inflammation, gut microbiome, and metabolism in mice, showing improvements in cytokine balance, microbial diversity, and fatty acid metabolism.

The paper reports the cryo-EM structure of SETD3 interacting with enterovirus protease 2A and shows that mutations in the SET domain reduce binding and protect against infection.

This study identifies RNA binding proteins essential for leukemic stem cell survival using an in vivo CRISPR screen and highlights ELAVL1 as a therapeutic target in AML.

The paper identifies a novel enhancer, NE1, that modulates Igh locus conformation and influences V(D)J recombination by altering chromatin structure and VH gene usage.

The paper reports the in situ structure of SARS-CoV-2 Delta variant virions and captures membrane fusion snapshots, revealing unique architectural features and fusion mechanisms.

This study shows EGCG protects against radiation-induced intestinal injury by preserving macrophages and gut microbiota, reducing inflammation and improving survival in mice.

This study shows that IDOL deficiency reduces atherosclerosis in rabbits fed a high-cholesterol diet by improving lipid metabolism and bile acid excretion.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study identifies Slc37a2 as a sugar transporter in osteoclast secretory lysosomes, showing its role in bone metabolism through dynamic tubular networks and its impact on bone mass.

HSP90.6 regulates maize grain filling by affecting 26S proteasome-mediated nitrogen recycling and GF14-6-mediated carbon metabolism.

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

This paper describes a scalable method for producing high-quality recombinant three-finger proteins using E. coli, enabling their use as molecular probes.

This study shows that near-neutral pH enhances n-caprylate production in a microbiome by inhibiting methanogenesis through undissociated n-caprylic acid.

This paper describes a method using calcineurin fusion to improve cryo-EM structure determination of Family A GPCRs by enhancing particle alignment.

This study identifies a chromosomal locus in Streptococcus gallolyticus subspecies gallolyticus that is critical for its pathogenicity in colorectal cancer.

This paper introduces a heat-shock protocol for wheat transformation that significantly improves efficiency using BBM-WUS, reducing the time to obtain transgenic plants to 60 days.

This paper develops a membrane-based method to extract and concentrate patchoulol from engineered microalgae, achieving lower solvent use and economic sustainability compared to existing methods.

This study evaluates autocalibration methods for accelerated EPI of the cervical spinal cord at 7T, finding that GRE and single-shot EPI ACS reduce artifacts better than FLEET or segmented EPI.

The paper reports cryo-EM structures of a Munc18-1-syntaxin-1-synaptobrevin complex, revealing how Munc18-1 facilitates SNARE complex assembly by mediating interactions between syntaxin-1 and synaptobrevin.

This study develops a chimeric mRNA vaccine that provides broad protection against Omicron and Delta variants of SARS-CoV-2 by combining RBDs from different variants.