J. Yan

The paper investigates how strain dropouts in the gut microbiome affect community metabolism and host physiology, finding that functionally redundant strains can have significant impacts outside their niche.

This study identifies ZmEREB57 as a maize AP2/ERF transcription factor that enhances salt stress tolerance by regulating OPDA and JA signaling through two distinct pathways.

The paper investigates subtype-specific mechanics of β1 integrins in cell spreading, showing different tension thresholds and cytoskeletal remodeling for integrin α4β1 versus RGD-binding integrins.

This paper identifies synthetic lethality between PRC2 inactivation and DNMT1 inhibition in MPNST, showing enhanced cytotoxicity through retrotransposon activation and innate immune signaling.

This study shows that PRC2 inactivation in tumors creates an immune-desert microenvironment, leading to resistance to immunotherapy and suggests strategies to reverse this effect.

This study investigates how hydrogel rheological properties affect depot formation and persistence after subcutaneous injection in mice.

This paper introduces Wolffia australiana as a model system for studying plant morphogenesis using a Plant-on-Chip culture system and advanced technologies like snRNA-seq.

This study quantifies the tension-dependent lifetime of tension gauge tethers to better understand their mechanical stability under physiological stretching conditions and reinterprets previous experimental observations.

This paper develops a LAG-3 immunohistochemistry assay for melanoma, demonstrating high specificity, sensitivity, and reproducibility for clinical use.

This paper identifies YM201636 and PI-103 as potent TPC2 channel blockers and shows His699 near the pore entrance is critical for their inhibitory effect.

This study shows cell mass homeostasis is maintained throughout the cell cycle, not just at G1/S, using ceQPM to measure dry mass in mammalian cells.

This study evaluates the effectiveness of various vaccine boosters against the Omicron variant following prime vaccinations with inactivated or adenovirus-vectored vaccines, finding that certain boosters significantly enhance neutralizing activity.

This paper develops an injectable hydrogel to co-deliver CAR-T cells and cytokines, enhancing solid tumor treatment in mice by creating a transient inflammatory niche.

This study shows that shared diffusible biofilm matrix proteins in Vibrio cholerae are susceptible to cheater exploitation, and their evolutionary stability depends on spatial structure, sharing mechanisms, and environmental flow conditions.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This study shows that slow release of an RBD subunit vaccine via hydrogel enhances neutralizing antibody responses against SARS-CoV-2 compared to bolus administration.

This paper develops a lung-selective Cas13d-based nanotherapy targeting Ctsl to inhibit SARS-CoV-2 infection, showing improved survival and reduced viral burden in mice.

This study investigates how mechanical tension regulates the stability and function of the HMP1-HMP2 protein complex in C. elegans, revealing its role in mechanotransduction.

The paper introduces a framework to address context-dependency in metacommunity research by analyzing four dimensions and testing their interactions through simulations.

This study compares a wild-type SARS-CoV-2 spike protein DNA vaccine with an optimized sequence in a mouse model, showing enhanced immune responses and protection against viral challenge.

The paper identifies Lsm12 as an NAADP receptor and TPC regulatory protein essential for Ca2+ mobilization from acidic organelles.

This study investigates how confined environments influence biofilm morphology and cell ordering in Vibrio cholerae using single-cell imaging and biomechanical analysis.

The paper identifies AtOPT3 as a phloem transporter that moves copper and iron, mediating shoot-to-root signaling and crosstalk between copper and iron homeostasis in A. thaliana.

This study develops a theoretical framework to explore how nucleus size affects chromatin structure and DNA-protein interactions in living cells.

The paper measures ligand-binding kinetics of integrin states and finds low-affinity states bind faster than the high-affinity state.

A cGAMP-containing hydrogel vaccine enhances RBD subunit vaccine efficacy by enabling sustained antigen and adjuvant delivery, resulting in broader and more potent antibody responses.

The paper improves a synthetic gut microbiota community by adding strains that persist after fecal challenge and removing those that do not, resulting in a more stable model of the human gut microbiome.

This paper develops an oncolytic viral vector-based vaccine that prevents COVID-19 and treats tumor progression in preclinical models.

This study shows that mechanical forces in Vibrio cholerae biofilms drive a reorientation cascade, creating a core-rim structure through differential growth and compressive stresses.

This study tracks the genomic evolution of ST11-CRKP during antibiotic therapy in a patient, identifying mutations linked to reduced virulence and increased host adaptation.