J. Yan

This study shows YTHDF2, an m6A reader, enhances NK cell anti-tumor and anti-viral responses by regulating homeostasis, maturation, and effector function through STAT5 feedback and Tardbp interactions.

The paper identifies actin polymerization regulators that drive chiral actin swirling and left-right asymmetry in single cells and cell collectives.

This study maps genetic diversity across Zea species, identifying millions of variants and adaptive genes, and demonstrates their utility in breeding.

This study identifies a direct interaction between CDK1 and talin at integrin adhesions, showing CDK1 modulates talin's mechanosensitivity and affects downstream mechanotransduction.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

This study shows that time-restricted feeding near dawn alters long-term mouse behavior through SCN GABAergic neurons by affecting exosome-related genes and Kcc2.

This study shows that Paracoccus aminovorans enhances Vibrio cholerae colonization in the murine intestine through dual-species biofilm formation dependent on VPS and other biofilm components.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This study presents the first de novo genome of Jasminum sambac and identifies gene clusters and pathways involved in flower fragrance biosynthesis.

This study shows that stretching forces trigger Ca2+ influx through L-type channels in filopodia, causing persistent Ca2+ oscillations that influence cell migration.

This study identifies a Krt5-BMP4 mechanosignaling pathway that regulates histone modifications and blastema cell remodeling during zebrafish heart regeneration.

This paper develops a rapid, sensitive, and low-cost nanozyme-based chemiluminescence paper test for SARS-CoV-2 antigen detection with results in under 16 minutes.

This study shows cingulin regulates apical and tight junction membrane mechanics by organizing myosin-2B and gamma-actin and modulating ZO-1 conformation in MDCK cells.

This study identifies an optimized mRNA UTR combination (NASAR) that significantly enhances SARS-CoV-2 antigen expression in vitro and in vivo.

This study shows Parkin orchestrates mitochondrial lipid remodeling through phospholipase D2 and Lipin-1 to drive mitophagy via DAG production and autophagosome formation.

This study identifies a non-canonical histone acetyltransferase in CYC/TB1-like proteins that regulates plant architecture by modifying histone H3 and activating gene expression.

This study shows that vinculin loss in murine skin disrupts adherens junctions, leading to loss of bulge stem cell quiescence through impaired force generation and YAP1 retention.

This study identifies qKW9, a gene affecting maize kernel weight by regulating photosynthesis through C-to-U editing of NdhB.

This study identifies sex pheromone plasmids as a mechanism for disseminating linezolid-resistance in E. faecalis through plasmid transfer.

This study evaluates how different storage conditions, preservation periods, and sequencing platforms affect gut microbiome profiles using 16S rRNA gene sequencing.

This study designs and evaluates TRAP-CSP fusion antigens as malaria vaccines, finding that those containing the CSP repeat region provide complete sterile protection in mice.

This paper identifies HMGA2 as a regulator of DNA supercoiling and replication fork stability, showing its protective role against DNA damage from topoisomerase poisons and its potential as a therapeutic marker in cancer.

This study investigates how a breast cancer GWAS variant may regulate immune cell gene expression in the tumor microenvironment, potentially affecting cancer progression.

The paper presents the genome of Aquilegia coerulea and shows extensive allele sharing and introgression among species, with a unique chromosome evolutionary history.

This study investigates how forces affect filopodia adhesion, showing that myosin IIA and formins are essential for force-dependent adhesion and substrate preference.

This study examines the longevity of dental restorations in geriatric and adult special needs patients over 15 years, finding median survival of 6.25 years and factors associated with restoration failure.

The paper shows that Shine-Dalgarno sequence accessibility affects N-terminal codon bias in E. coli by modulating translation initiation efficiency.

This study shows that force-dependent vinculin binding to α-catenin stabilizes adherens junctions and regulates cell-cell contact dynamics and collective cell behavior.