J. Zhang

This study shows that Arabidopsis PPC2 is essential for growth at low CO2 by linking photorespiratory metabolism with primary metabolism and ABA signaling.

This study shows that the OR1D2 receptor mediates bourgeonal-induced CatSper activation through a G-protein-cAMP pathway in human sperm.

The paper identifies heat-regulated yeast proteins that localize to stress granules, showing intrinsically disordered regions (IDRs) are sufficient for SG recruitment and play a critical role in heat-stress response.

This study uses genomics to determine the geographical origins of ancient butterfly specimens, resolving long-standing taxonomic disputes and demonstrating the utility of ancient DNA in species delineation.

This study shows that HMGB1 release in response to mechanical overloading causes inflammation and tendinopathy in mice, which can be blocked by glycyrrhizin.

This study investigates sex chromosome evolution in paleognath birds, finding that tinamous have higher substitution rates and unique evolutionary strata without chromosomal inversion.

This paper introduces NIPSS, a nanopore sequencing method for direct miRNA sequencing, demonstrating single-molecule resolution and potential applications in cancer diagnostics and therapeutics.

The paper investigates the role of xa5 in BLS resistance by analyzing transcriptome changes in Xa5-RNAi rice lines compared to wild-type, finding enhanced cell death gene responses.

The paper models calcium-induced cAMP/PKA dynamics in dendritic spines, showing that the pathway filters high-frequency calcium inputs to respond only to lower frequencies.

This study identifies AGL16 as a negative regulator of drought resistance in plants by modulating stomatal density and ABA levels through transcriptional regulation of key genes.

This paper introduces three novel concepts to aid in designing multi-drug adaptive therapies for cancer by analyzing tumor evolution dynamics and treatment strategies.

This study evaluates how golden apple snail residues affect soil properties and bacterial communities, finding that they increase soil nutrients and alter bacterial diversity and composition.

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

The paper shows that cAMP-PKA-CREB signaling in cDC2s represses IRF4 and KLF4, promoting Th17 responses and inhibiting Th2, with similar effects observed through PRR-dependent signals like curdlan.

The paper shows Bcl-2 and Bcl-xL reduce autophagic cell death in polyploid cells treated with Aurora-B kinase inhibitors, contributing to resistance to these drugs.

This study identifies LIS1's role in promoting dynein activation by switching it from an auto-inhibited to active state through cargo-adapter interactions in Aspergillus nidulans.

The paper develops a physiology-based model to predict and interpret pediatric oxygen saturation at high altitudes, showing it better identifies normal ranges than statistical thresholds.

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

This study examines tannin and saponin degradation during co-composting of Camellia oleifera shell and seed cake, finding that higher seed cake proportions increase degradation rates but reduce C/N ratio and tannin content.

The paper shows that mice lacking HRG1 accumulate excess heme in macrophages, which they tolerate by forming hemozoin, a process previously only observed in blood-feeding parasites.

This paper develops and validates a Quantitative Dot Blot (QDB) method for absolute quantification of Her2 in FFPE breast cancer tissues, showing high correlation and diagnostic accuracy comparable to IHC and FISH.

This study shows that SCFAs from gut microbiota stimulate GLP-1 secretion in chickens, which suppresses hepatic lipogenesis.

This paper classifies lung adenocarcinomas into six subtypes based on EGFR, KRAS, and TP53 mutations, finding associations with prognosis and validating the classification against clinical outcomes.

The paper detects Leishmania spp. in snakes from Northwest China and identifies three species using phylogenetic analysis.

This study identifies βVPE as a key enzyme in Arabidopsis thaliana that activates proproteases for tapetal degradation and pollen development.

This study shows NAD+ increases antioxidant capacity in PC12 cells through SIRT2, ERK, and Nrf2 pathways under basal conditions.

This paper develops an optogenetic method to control mitochondrial membrane potential and shows its effects on cell fate, finding that light-induced depolarization can induce apoptosis or cytoprotection depending on duration and intensity.

The paper examines diminishing returns epistasis in yeast across environments, finding it widespread and showing environmental quality affects mutation benefits independently of fitness.

This study characterizes the rhizosphere fungal community structure of tetraploid cotton and finds it varies with soil type, cotton genotype, and developmental stage.