J. Zhang

This study characterizes the structural, functional, and antigenic properties of SARS-CoV-2 Omicron BA.2 spike protein and compares its replication efficiency with previous variants.

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

This study identifies how flavivirus prM proteins interact with MDA5 and MAVS to inhibit RLR antiviral signaling, revealing species-dependent immune evasion mechanisms.

This paper introduces a method to rapidly image biomechanics with low irradiation using dual line-scanning Brillouin microscopy, demonstrating its application to study tumor spheroid mechanics.

The paper identifies MME+ fibro-adipogenic progenitors as the main adipogenic population in fatty infiltrated human skeletal muscle using single-cell RNA sequencing.

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.

The paper identifies HMGR as a potential herbicide target and demonstrates the design of specific inhibitors and a tolerance trait.

The paper identifies a 48-gene prognostic signature and synthetic-lethality profiles predictive of survival and therapy response in mesothelioma using transcriptomic and exomic data from 122 patients.

This study compares genomes of orobanchaceous plants with different parasitic lifestyles to trace the evolutionary steps of plant parasitism.

This paper reports a synthetic nanobody, C5G2, that neutralizes SARS-CoV-2 and Omicron variants with high potency through a unique binding mechanism.

This paper develops an ultra-high-throughput method for microbial single-cell whole genome sequencing to study microbial dark matter and improve metagenomic analysis.

This study examines the evolutionary responses of the coral Acropora digitifera to climate change by analyzing genetic divergence and adaptation mechanisms during the last glacial maximum.

This study develops a mosaic-type trimeric RBD vaccine that induces strong neutralizing antibodies against Omicron and other SARS-CoV-2 variants in rats.

This study maps single-cell transcriptomes and T cell repertoires in Behcet's disease to identify immune mechanisms and T cell trajectories in vascular and dermal manifestations.

The paper identifies a gain-of-function in the wheat Lr67res protein variant, associated with anion fluxes, which contributes to multi-pathogen resistance.

This study develops a hyperspectral imaging-based method to monitor leaf chlorophyll content and assess glyphosate tolerance in maize seedlings using chlorophyll a fluorescence and chemometrics.

The paper evaluates five compost-based substrates for Camellia oleifera seedling cultivation, finding that a specific combination yields optimal growth and survival rates.

This study shows that asymmetric ABA response in tomato root tips mediates proton efflux and cell elongation, driving hydrotropic bending toward water.

This study identifies HERV activation in BA livers and shows it re-educates macrophages, impairing neutrophil recruitment and causing liver damage, suggesting therapeutic targets.

The paper identifies KASH5 as a dynein activating adaptor essential for meiotic chromosomal movements, showing it binds dynein and enables processive motility.

The paper shows lamin A/C enables nuclear deformation through fibrous environments by acting like surface tension, allowing nuclei to bypass obstacles without rupturing.

The paper identifies CD274-expressing cells in human lungs that are expanded in IPF and show progenitor-like behavior in ex vivo assays.

The paper examines gender disparities in question-asking behavior at a virtual conference, finding women asked half as many questions as men despite equal attendance.

This study shows SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion by altering its structure and function.

The paper investigates how alternative 3' UTRs regulate gene expression in response to high salt stress in Spartina alterniflora, showing that 3' UTR lengthening enhances RNA stability and protein synthesis of stress-related genes.

The paper develops a method to rapidly quantify PHA in living cells using GFP-labeled phasins, achieving high accuracy with R-squares over 0.9.

The paper analyzes the demographic history of monarch butterflies and milkweed over 12,000 years, finding concurrent range expansions but no recent population contractions in either species.

The paper identifies hpm91, a Chlamydomonas mutant with high hydrogen production, as scalable and robust for large-scale algal H2 photoproduction.

This study infects neonate and adult mice with dengue virus via the nasal route, showing viral tropism and replication in multiple tissues, suggesting respiratory transmission as a potential non-vector route.

The study compares antigen-antibody interactions at different states using QDB, showing conformational epitopes dominate interactions, challenging Western blot as a validation tool for IHC and ELISA antibodies.