J. Zhou

This study shows metformin reduces TNF-α production in B cells of PCOS patients and mice by inhibiting mTOR and altering metabolism.

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

The paper identifies amyloidogenic peptides in SARS-CoV-2 that are toxic to neuronal cells, suggesting they may contribute to neurological symptoms and long COVID.

This study shows that two pheasant species have experienced recurrent gene flow during speciation, with evidence of long-term gene flow after initial divergence and ongoing contact in recent times.

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

This study shows that malaria parasites use pyrophosphate to power a proton pump essential for ring stage development and transition to trophozoite stage.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This paper demonstrates that the orb-weaving spider uses its web as an acoustic sensor to detect and localize airborne sounds, surpassing the efficiency of known eardrums.

This study shows pVHL regulates TCF/LEF protein stability via ubiquitin-independent proteasomal degradation, revealing a novel mechanism in Wnt/β-catenin signaling.

This study identifies POU-IV as a key regulator of hair cell development in the sea anemone Nematostella vectensis, revealing its ancient role in mechanoreceptor identity.

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

This study shows SMC1A promotes gastric cancer progression by enhancing SNAI2-driven EMT, suggesting it as a therapeutic target.

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

This study shows that TFR1-mediated iron uptake in osteoclasts affects mitochondrial function and cytoskeleton, leading to increased bone mass in female mice.

This study examines gut microbiota composition in GDM patients before and after diet intervention, finding that diet affects the Firmicutes/Bacteroidetes ratio and specific taxa rather than altering the overall microbial pattern.

This study shows that a 3D microenvironment enhances BBB phenotype and function in iPSC-derived microvessels compared to 2D cultures.

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.

This paper introduces a chemogenetic switch for CAR-T cells using HCV-NS3 protease, enabling controlled activation through ASV concentration modulation.

The paper identifies spike mutations that adapt SARS-CoV-2 to mustelid hosts and assesses their impact on human infectivity and antigenicity.

The paper establishes a bacterial genome and culture collection of the piglet gut microbiome, revealing new species and functional insights.

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

This study shows BTKi treatment reduces APOBEC3 expression in CLL B cells through enhancer regulation, linking BCR signaling to genomic instability.

The paper develops antibodies targeting proteolytic neo-epitopes of CDCP1 in RAS-driven cancers, showing improved tumor specificity and safety.

This study identifies MmcA as a key outer-surface c-type cytochrome for DIET in M. acetivorans and shows that archaella and other membrane complexes are involved in electron processing for methane production.

This study identifies molecular subtypes of prostate cancer using multi-omics data and clustering algorithms, revealing distinct clinical and biological features associated with each subtype.

This study identifies OsK5.2, an outward K+ channel, as a key determinant of rice salt tolerance by facilitating K+ translocation and reducing Na+ accumulation in leaves.

This study shows SARS-CoV-2 B.1.617 variants have enhanced spike cleavage by furin due to the P681R mutation, potentially increasing transmissibility and pathogenicity.

This study demonstrates that a natural microbial community can sustain nitrate removal from groundwater even after prolonged absence of an electron donor.

The paper elucidates the dideoxygenation mechanism in gentamicin biosynthesis, showing how intermediates JI-20A and JI-20B are converted to gentamicin C complex through phosphorylation and PLP-dependent enzymatic reactions.

This study evaluates the replication, antibody sensitivity, and vaccine efficacy of the SARS-CoV-2 B.1.617.2 Delta variant compared to other variants and vaccine-elicited immunity.