J. Zhou

This paper identifies a new family of 'Ca. Nanohaloarchaeota' from hypersaline environments, showing they are an intermediate stage in the evolution of symbiosis with Halobacteria.

This study shows Delta and Omicron SARS-CoV-2 variants do not provide cross-protective immunity against reinfection in hamsters.

This study identifies distinct gut microbiome signatures in adult atopic dermatitis patients compared to healthy individuals in southern China.

The paper uses cell-type-specific transcriptomics to show how WCS417 affects root cell types, revealing roles for root hairs in immunity and endodermal barriers in beneficial association.

This study shows that hybrid immunity and vaccine boosters provide potent neutralizing activity against Omicron BA.1 and BA.2, while breakthrough infections induce nasal mucosal neutralization and identify an ultrapotent pan-variant antibody.

This study analyzes Usutu virus genomes to identify lineage-specific codon usage patterns and host adaptation mechanisms.

The paper identifies maternal and embryonic signaling-driven differentiation of luminal epithelial cells in the mouse endometrium and shows conservation in humans.

This study compares the transcriptomes of Geobacter metallireducens during DIET with different electron-accepting partners, showing varied gene expression and requirements for DIET.

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

This study develops a miniaturized ultrasound transducer for full-mouth oral health monitoring, demonstrating high-resolution imaging and accurate gingival thickness measurement.

The paper shows that hypoxia induced by pinewood nematode (PWN) loading increases tracheal elasticity and ECM thickness in beetles, enhancing PWN transmission.

This study shows that TSS inhibits the TLR3 pathway, reducing CVB3 infection severity in mice and cell cultures.

This study identifies a conserved mechanism by which pH-sensing regions regulate reversible amyloid formation in pyruvate kinase across yeast and human cells.

The paper identifies a novel role of the pyruvate dehydrogenase complex in regulating mitophagic selectivity independently of its enzymatic activity.

This study shows hyperuricemia induces renal tubular epithelial pyroptosis via ROS-mediated NLRP3 inflammasome activation in cultured cells and rat models.

This paper develops hetero-bivalent nanobodies that neutralize multiple SARS-CoV-2 variants, including Omicron, and show protective effects in vivo.

This study identifies critical ecological protection areas in Aksu City and Wensu County by simulating human activity impacts and analyzing resistance surfaces across different scenarios.

The paper shows TBK1 phosphorylates TNIP1, activating its LIR-dependent autophagy-mediated degradation, which promotes pro-inflammatory gene expression.

The paper develops a high-throughput method to functionally evaluate natively paired human T cell receptors against multiple pMHCs, validated through affinity-based mapping and sequencing.

LabGym quantifies user-defined animal behaviors using a learning-based approach, providing holistic assessment without pre-defined features or species restrictions.

This paper develops temperature-sensitive nanothermometry probes to measure spatiotemporal thermodynamics of lysosomes and mitochondria in living cells, revealing distinct thermal responses to metabolic perturbations.

The paper shows fish oil nano-emulsions trigger ferroptosis and autophagy in macrophages via catalase-catalyzed superoxide production, leading to oxidative damage.

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

This study identifies distinct genetic determinants in the Omicron spike protein for altered cell entry and antigenic properties, showing they are separable and may affect future variant severity and vaccine efficacy.

This study compares the severity of SARS-CoV-2 Omicron-B.1.1.529, Pango B, and Delta variants in a mouse model, finding Omicron causes less severe disease with lower viral load and inflammation.

This paper introduces self-confocal NIR-II fluorescence microscopy systems for in vivo imaging, improving adjustability and enabling cerebrovascular and hepatic imaging.

This study investigates the biogenesis of mitochondrial outer membrane multi-span proteins using yeast and Om14, showing that both protein factors and membrane properties influence their integration.

This study investigates the effect of moxibustion on colorectal cancer liver metastasis using animal models, finding reduced metastasis rates and identifying potential molecular targets.

This study identifies CXCL8/CXCR2 signaling as a driver of bone marrow fibrosis in myelofibrosis and shows its therapeutic potential through genetic and pharmacologic inhibition.