L. Cui

Illuminating host-mycobacterial interactions with functional genomic screening to inhibit mycobacterial pathogenesis

This study uses CRISPR screens to identify host genes that inhibit mycobacterial growth, revealing potential targets for host-directed tuberculosis therapies.

HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV

This paper evaluates HTCC as a potential inhibitor for SARS-CoV-2 and MERS-CoV, highlighting its antiviral activity against highly pathogenic coronaviruses.

Internally quenched fluorogenic probe provides selective and rapid detection of cathepsin L activity

The paper introduces CTLAP, a fluorogenic probe that selectively and rapidly detects cathepsin L activity with improved selectivity and turn-on ratio compared to existing probes.

A Self-Immobilizing NIR Probe for Non-invasive Imaging of Senescence

The paper develops a self-immobilizing NIR probe activated by SA-β-Gal for non-invasive imaging of senescence in mice.

Ultrasensitive small molecule fluorogenic probe for human heparanase

This paper introduces an ultrasensitive fluorogenic probe for detecting human heparanase activity with a picomolar detection limit and demonstrates its use in high-throughput inhibitor screening.

Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity

This study shows JUN activation in fibroblasts drives fibrosis and modulates immunity, with therapeutic potential through targeting IL-6, CD47, and PD-L1.

NbCycB2 represses Nbwo activity via a negative feedback loop in the tobacco trichome development

Responsive fluorophore aggregation provides spectral contrast for fluorescence lifetime imaging

The paper develops a fluorescent probe that changes emission lifetime upon aggregation, demonstrating potential for responsive imaging probes.

Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria

This study develops CRISPR-Cas13a-based antimicrobials that kill target bacteria by cleaving RNA, showing effectiveness against carbapenem-resistant E. coli and methicillin-resistant S. aureus.

An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans

The paper develops an inflammatory clock of aging (iAge) using blood immunome data from 1001 individuals, showing it correlates with multi-morbidity, immunosenescence, and cardiovascular aging.

Composition and Diversity of CRISPR-Cas13a systems in the genus Leptotrichia

The paper analyzes CRISPR-Cas13a and other CRISPR-Cas systems in 11 Leptotrichia strains, revealing their diversity, distribution, and evolutionary relationships.

Analysis host-recognition mechanism of staphylococcal kayvirus phiSA039 reveals a novel strategy that protects Staphylococcus aureus against infection by Staphylococcus pseudintermedius Siphoviridae phages

This study identifies a novel host-recognition mechanism in the kayvirus phiSA039 that allows it to infect both Staphylococcus aureus and S. pseudintermedius by adapting its receptor and exploiting differences in WTA glycosylation.

Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors

This study uses genome-wide CRISPR-dCas9 screens in E. coli to identify essential genes and phage host factors, revealing colanic acid capsule as a barrier to phages.

Oxidative stress resistance and fitness-compensatory response in vancomycin-intermediate Staphylococcus aureus (VISA)

This study shows VISA strains with vraS and/or graR mutations are more resistant to oxidative stress, leading to reduced survival in infected C. elegans.

Revealing The Cell-Material Interface With Nanometer Resolution By FIB-SEM

This paper introduces a method to visualize the cell-material interface at nanometer resolution using FIB-SEM, enabling detailed study of cell-material interactions.