L. Lin

This study identifies that DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctions, suggesting MMP-9 as a potential therapeutic target for severe dengue.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

This paper presents a mobile microscopy and telemedicine platform with deep learning for automated quantification of Trichuris trichiura infection, achieving high precision and recall in stool sample analysis.

This study uses artificial neural networks to detect and reverse myocardial ischemia through bioelectronic medicine, achieving high accuracy and effective biomarker reversal.

This study evaluates the effects of MSM and sesame seed oil on lipid profiles and PUFA metabolism in db/db mice, finding improved HDL and reduced non-HDL cholesterol with combination treatment.

This study shows Ox-LDL, not AngII, induces LOX-1 and AT1-R interaction, leading to cardiomyocyte hypertrophy via Gq protein activation.

This study measures CTC kinetics and metastatic potential by exchanging blood between tumor-bearing and healthy mice, finding short CTC half-life and high shedding rates.

This paper develops a numerical model to study how external electric fields at resonant frequencies deform cells, showing increased response at resonance and potential for cell rupture.

The paper presents an improved strategy for deep N-glycomics with optimized sample prep, isotope-based QC, new libraries, and algorithms, but the manuscript was withdrawn due to incomplete data.

This paper develops flexible, transparent silver nanowire microelectrodes for multifunctional biointerfacing, showing high optical transparency, low impedance, and good biocompatibility in heart monitoring.

This study identifies EGFR downregulation as a mechanism by which HPV infection improves prognosis in cervical and head and neck cancers, suggesting EGFR inhibitors could be potential anti-HPV therapies.

This study shows that inhibiting FATP2 in MDSCs reduces ROS and enhances anti-PD-L1 immunotherapy by improving T-cell function and reducing PD-L1 expression.

This study identifies CD90+ fibro-adipogenic progenitors in T2DM skeletal muscle and shows PDGF signaling drives their pathogenic behavior, which is mitigated by Metformin.

This study uses mass spectrometry to compare mutations in Pandemrix and Arepanrix vaccines, finding differences in protein modifications that may explain varying narcolepsy risks.

This study shows that the pancreatic tumor microenvironment compensates for loss of GOT2 by providing pyruvate, maintaining redox homeostasis and tumor growth in vivo.

This study discovers and characterizes skeletostatins, selective skeletal myosin II inhibitors with improved properties for research and drug development.

The paper develops a covariance-based method for spatial binary data analysis using GLMMs to study genetic patterns in infectious disease spread.

This study investigates the role of ESR1-CCDC170 gene fusions in breast cancer endocrine resistance, showing they reduce endocrine sensitivity and can be targeted with HER2/SRC inhibitors.

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

A computational method expands the structure space of designer proteins by systematically sampling loop-helix-loop geometries.

This study tracks gut microbiome diversity and composition changes in gynecologic cancer patients undergoing chemoradiotherapy, finding reduced diversity during treatment but partial recovery by week 12.

The paper identifies core transcription factors regulating root growth in soybean under water deficit by integrating phylogenetic analysis and transcriptome data.

This study shows that inhibiting GOT1 in pancreatic cancer primes cells for ferroptosis by promoting autophagy-mediated release of labile iron.

This study investigates how antler polypeptide affects the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells, finding that antler polypeptide B significantly enhances these processes.

This study examines the effects of atrazine exposure on DNA methylation and gene expression in zebrafish, identifying specific genes and pathways affected by the herbicide.

The paper shows that pancreatic ductal adenocarcinoma (PDA) is more dependent on GOT1 than colorectal cancer (CRC) and that GOT1 inhibition synergizes with radiotherapy to inhibit PDA growth.

This study shows that GIT1 and β-Pix form a condensed enzyme complex via phase separation, enabling compartmentalized signaling in different cellular contexts.

This study identifies riboflavin as a direct mediator of electron transfer in microbial P450 monooxygenase dealkylation, revealing a novel mechanism involving FAD/FMN cofactors.

This paper introduces membrane expansion microscopy (mExM), a technique for nanoscale optical imaging of lipid membranes with improved resolution for studying protein-lipid interactions in organelles.